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題 名 | Hemodynamic and Neurohumoral Changes after Abdominal Aortic Constriction in Rats=老鼠的流體力學及神經活性在主動脈窄縮後的變化 |
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作 者 | 黃碧桃; 歐天元; 胡振濤; 陳幸一; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷 期 | 23:4 1999.10[民88.10] |
頁 次 | 頁149-157 |
分類號 | 415.38 |
關鍵詞 | 老鼠; 流體力學; 神經活性; 主動脈窄縮; Aortic constriction; Cardiac hypertrophy; Hemodynamic; Renin; Sympatho-adrenergic system; |
語 文 | 英文(English) |
英文摘要 | Cardiac after-load, neurohumoral reaction and the secondary cardiac hypertrophy were studied in six groups of Sprague-Dawley (SD) rats with abdominal aortic constriction. We found that abdominal aortic constriction above the renal arteries decreased the heart rate and cardiac output, and increased the pulse pressure. These abnormalities would return to normal after constriction ended. Captopril, propranolol and prazosin could reduce the increase of pulse pressure but still had decreased in cardiac output of rats with abdominal constriction. Aortic constriction also increased the aortic impedance and cardiac load but decreased aortic compliance. These changes could also be lessened by captopril, propranolol and prazosin. We have confirmed that aortic constriction can induce secondary cardiac hypertrophy, but the pathogenesis might be due to multiple factors. |
本系統中英文摘要資訊取自各篇刊載內容。