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頁籤選單縮合
題 名 | 天麻、鉤藤對Kainic Acid誘發癲癇發作老鼠效用之研究=A Study in the Effect of Tien-Ma and Kou-Teng on Rat with Kainic Acid-Induced Seizures |
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作 者 | 謝慶良; | 書刊名 | 中醫藥年報 |
卷 期 | 17:2 1999.05[民88.05] |
頁 次 | 頁443-457 |
分類號 | 414.5 |
關鍵詞 | 抗痙攣作用; 鉤藤; 脂質過氧化作用; 腦波; Anticonvulsant effect; Vanillyl alchol; Catechin; Uncaria rhychophlla; Kainic acid; Wet dog shakes; Lipi-peroxidation; EEG; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究的目的是在探討vanillyl alchol(VA),catechin和鉤藤的抗痙攣效用及其 作用的生理機轉。總共 116 隻男性的 Sprague-Dawley (SD ) 老鼠被使用來做研究,70 隻 在 kainic acid (KA,12 mg/kg) 腹腔注射前 30 分鐘分別使用 VA 200 mg/kg, 100 mg/g , catechin 100 mg/kg, 50 mg/kg, 鉤藤 1000 mg/kg, 500 mg/kg, 250 mg/kg 和 Carbamazepine 20 mg/kg 腹腔注射。 整個實驗過程都施行行為觀察和腦波及肌電圖記錄。 抗癲癇效果的評估是根據每 10 分鐘間隔的 wet dOg Shakes 發作次數。 36 隻 SD 老鼠在 kainic acid (12 mg/kg) 注射前 30 分鐘分別施行鉤藤 1000 mg/kg, 500 mg/kg, 250 mg/kg 和 Carbamazepine 20 mg/kg 腹腔注射,然後在 KA 投予後一小時犧牲取腦,最後利 用 TBA (thiobarbituric acid) 法著測定 MDA (ma1Onda1hyde) 濃度來決定大腦皮質的脂 質過氧化濃度。 我們的結果顯示 VA 200 mg/kg,100 mglkg, catechin 100 mg/kg,鉤藤 1000 mg/kg 和 500 mg/kg 可以減少 KA 引發 wet dog shakes 的發作次數, 但 catechin 50 mg/kg 鉤藤 250 mg/kg 和 carbamazepine 20 mg/kg 沒有相似的效果。 鉤藤 1000 mg/kg,500 mg/kg,250 mg/kg 和 carbamazepine 20 mg/kg 可以減少 KA 發的大腦皮質脂 質過氧化的濃度。 鉤藤 1000 mg/kg 顯示最強的脂質過氧化抑制作用, 其次是鉤藤 mg/kg 和 250 mg/kg,最小的 carbamazepine20mg/kg。根據我們的結果 VA200mg/kg,100mg/kg, catechin 100 mg/kg, 鉤藤 1000mg/kg 和 500mg/kg 可以減少 kainic acid 引發的 wet dog shakes 的發作次數,猜想 VA,catechin 和鉤藤有抗痙攣作用。 鉤藤可以減少脂質過 氧化的濃度,猜想鉤藤有抑制脂質過氧化的作用。鉤藤的抗痙攣作用和抑制脂質過氧化作用 兩者都是與劑量的大小成正比的關係,如此我們猜想鉤藤的抗痙攣作用可能源於它的抗脂質 過氧化作用。 |
英文摘要 | This study investigated the anticonvulsant effect of vanillyl alchol (VA), catechin and uncaria rhynchophylla (UR) and the physiological mechanisms of its action in rats. A total of 116 male Sprague-Dawley (SD) rats were selected for study, 70 of the 116 rats recevied intraperitoneal injection (i.p.) of VA 200 mg/kg, 100 mg/kg, catechin 100 mg/kg, 50 mg/kg, UR 1000 mg/kg, 500 mg/kg, 250 mg/kg and carbamazepine 20 mg/kg 30 min prior to kainic acid (kA,12 mh/kg) administration, respectively. Throughout the experimental course. behavioral observation, and EEG and EMG recordings were performed. The anticonvulsant effect was evaluated by the numbner of wet dog shakes at 10 min interval. The 36 rats were used to measure the lipid peroxide level in the cerebral cortex one hour after KA administration. These rats received UR 1000 mg/kg, 500 mg/kg, 250 mg/kg and carbamazepine 20 mg/kg i.p. respectively, 30 min prior to KA administration. Our results indicated that VA 200 mg/kg, 100 mg/kg, catechin 100 mg.kg, UR 1000 mg/kg and 500 mg/kg decreased the incidence of KA-induced wet dog shakes, behavior no similar effect was observed in the catechin 50 mg/kg, UR 250 mg/kg and carbamazepine 20 mg/kg group. Treatment with UR 1000 mg/kg, 500 mg/kg, or 250 mg/kg and carbamazepine 20 mg/kg decreased KA-induced lipid peroxide level in the cerebral cortex. The UR 1000 mg/kg group showed the greatest suppressive effect on lipid peroxidation, followed by UR 500 mg/kg, UR 250 mg/kg, and finally carbamazepine 20 mg/kg exhibited the smallest suppressive effect. The results of this study suggest that VA 200 mg/kg, 100 mg/kg, catechin 100 mg/kg, UR 1000 mg/kg and UR 500 mg/kg may decrease the incidence of KA-induced wet dog shakes in rats, and that VA, catechin and UR therefore have an anticonvulsant effect. UR also decreased the KA induced-lipid peroxide increase, suggesting that UR has a suppressive effect on lipid peroxidation. Both the anticonvulsant and suppressive effects of UR are a dose dependent. These findings suggest that the anticonvulsant effect of UR possibly results from its suppressive effect on lpid peroxidation in the brain. |
本系統中英文摘要資訊取自各篇刊載內容。