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題 名 | Displacement Effect of Valproate on Bilirubin-Albumin Binding in Human Plasma=Valproate在人體血漿中可置換膽紅素-白蛋白之結合 |
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作 者 | 余秀瑛; 沈友仁; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 98:3 1999.03[民88.03] |
頁 次 | 頁201-204 |
分類號 | 414.7 |
關鍵詞 | 血漿; 膽紅素-白蛋白; Valproate; Bilirubin-albumin binding; Binding displacement; Free bilirubin; |
語 文 | 英文(English) |
英文摘要 | Drugs that can displace bilirubin from plasma albumin binding may cause various late manifestations of brain damage if given to newborns with unconjugated hyperbilirubinemia. The purpose of this study was to examine the displacement effect of valproate (VPA) on bilirubin- albumin binding in human serum albumin (HSA) and human plasma. Bilirubin-HSA solution and bilirubin-plasma solution containing no or serial concentrations of VPA were prepared, and free bilirubin in these solutions was measured by the enzyme oxidation method. VPA displaced bilirubin from bound bilirubin-albumin. The binding constant (K ) of VPA to the high affinity bilirubin- binding site of HSA and plasma protein were 11.6 L/mmol and 9.0 L/mmol respectively. The displacement effect may occur at the clinical concentration range of VPA, with a maximal displacing factor of 1.5 to 4.7. These results suggest that the clinician should use VPA in jaundiced neonates with caution. |
本系統中英文摘要資訊取自各篇刊載內容。