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頁籤選單縮合
題 名 | The Role of Heparin in Treatment of Purpura Fulminans: Experience in Four Cases=肝素在猛爆型紫斑症治療所扮演的角色--四兒童病例之經驗 |
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作 者 | 江東和; 呂嘉順; 林思偕; | 書刊名 | 慈濟醫學 |
卷 期 | 11:1 1999.03[民88.03] |
頁 次 | 頁97-101 |
分類號 | 417.5637 |
關鍵詞 | 猛爆型紫斑症; 肝素; 新鮮冷凍血漿; Purpura fulminans; Heparin; Fresh frozen plasma; |
語 文 | 英文(English) |
中文摘要 | 猛爆型紫斑症雖為一罕見之致死性疾病, 腦膜炎雙球菌造成的敗血症和腦膜炎是 常發病原因。臨床上其常發生在一相當健康的兒童,症狀包括表皮出血、肢體壞疽經常伴隨 著休克而致死。我們在最近的兩年處理過四例病例,有三位是由於腦膜炎雙球菌造成的。前 兩位患者均在轉入院四十八小時內死亡,後兩位病童則是給予及時的抗生素、肝素與輸血治 療而得以存活且僅有些微皮膚後遺症。我們認為早期確定診斷與及時投予肝素治療可以及時 挽回生命甚至完全痊癒。 |
英文摘要 | Purpura fulminans, most commonly seen in previously healthy children associated with meningococcal sepsis and meningitis, is a rare catastrophic disease with initial hemorrhagic skin lesions rapidly progressing to gangrene accompanied by shock and frequently resulting in death. We encountered patients with purpura fulminans since 1996; three of whose blood culture yielded Neisseria meningitidis. The first two patients died within 48 hours of admission despite aggressive therapy. The latter two patients received treatment of unfractionated intravenous heparin (10-15 IU/kg/h), in addition to antibiotics, and blood product replacement. Both survived with minimal cutaneous sequelae. We deem that with early recognition of this disease and prompt administration of heparin with proper treatment in htese patients, a full recovery may be expected. |
本系統中英文摘要資訊取自各篇刊載內容。