相關文獻
- 犬血液透析時血液流速與肝素劑量之相關研究(1)
- 血液透析處方之臨床實用準則(2)--血清尿素氮取樣及透析器再使用
- 肝素及Ticlopidine於犬血液透析之抗凝研究
- 中空纖維與血液透析之研究
- A Low Molecular Weight Heparin (Fragmin) in Reused Dialyzer for Hemodialysis
- Low Molecular Weight Heparin in Diabetic and Nondiabetic Hypercholesterolemic Patients Receiving Long-Term Hemodialysis
- 犬之急性腎衰竭與血液透析病例報告
- 長期血液透析患者的多次自發性後腹腔出血:一病例報告
- 低分子量肝素於血液透析的應用
- Clinical Study of A Nano Structure FX80 Hollow Fiber Dialyzer
題 名 | 犬血液透析時血液流速與肝素劑量之相關研究(1)=The Related Study of Blood Flow Rate and Heparin Dosage on Hemodialysis in Dogs(Ⅰ) |
---|---|
作 者 | 黃建元; 林琇玲; 陳光陽; |
書刊名 | 中華民國獸醫學會雜誌 |
卷 期 | 24:4 1998.12[民87.12] |
頁 次 | 頁236-243 |
分類號 | 437.25 |
關鍵詞 | 血液透析; 肝素; 血液流速; 透析器; 犬; Hemodialysis; Heparin; Blood flow rate; Dialyzer; Dogs; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究係針對血液流速和肝素投與量之改變,探討犬隻血液透析時體外循環之血 凝狀況。實驗對象為體重11-23公斤之健康成犬6頭,經麻醉後,由左、右外頸靜脈各安量 1條血液透析專用之單腔導管作為暫時性血管通路,待靜注麻醉劑失去作用後,再進行血液 透析達3個小時。試驗內容分為兩大部份,第一部份是將血液流速固定為30mL╱min,其 中又分為三種不同肝素劑量組(40 U╱kg+30U╱kg╱hr,70U╱kg+50U╱kg╱hr,100U ╱kg+70U╱kg╱hr);另一部份則將肝素劑量設定在70U╱kg+50U╱kg╱hr,再分成兩種 不同血液流速組(30mL╱min,100mL╱min)。結果顯示:在血液流速固定為30mL╱min 時,由血液迴路管動、靜脈端採血檢測之APTT值,三種肝素劑量組間都有極其顯著的差 異(p<0.01),且肝素劑量愈高,抗凝時間明顯加長,而三種肝素劑量組之透析器經烘乾後, 固體血液重量並無明顯差異(p>0.05, n=5),但在低肝素劑量組(40U+30U),則有1頭實 驗犬在透析快結束時,於迴路管之動、靜脈腔室內發現有嚴重凝血塊形成,尤其靜脈腔室內 之過瀘管周圍更全被凝血塊包圍住,致使體外循環之全部血量無法趕回動物體內;再者,肝 素劑量設定在70U+50U之高流速組,雖從靜脈端所測得之APTT值明顯比低流速組小(p <0.05),在動脈端方面,則無統計學上之差異(p>0.05),然其透析器內殘留之固體血液重 量明顯比低流速組輕(p<0.05, n=4),但在兩組之動、靜脈腔室內則幾無血塊形成。由此可 見,犬隻進行血液透析時,肝素之使用劑量仍然相當重要,且提高血液流速亦可減輕體外循 環凝血現象的發生。 |
英文摘要 | This study was undertaken to investigate the effects of blood flow rate and heparin dosage on blood clot formation of extracorporeal circulation on hemodialysis in dogs. Six healthy dogs of 11-23 kg body weight were anesthetized with pentobarbital-sodium, and single-lumen catheters were inserted temporarily into bilateral external jugular veins. Experiment I had the constant blood flow rate (30 mL/min) with three different heparin regimens (40 U/kg + 30 U/kg/hr, 70 U/kg + 50 U/kg/hr, 100 U/kg + 70 U/kg/hr). Experiment II had one heparin regimen (70 U kg +50 U/kg/hr) with two different blood flow rate regimens (30 mL/min, 100 mL/min). Hemodialysis was performed when the dogs were recovered from anesthesia. Each session lasted for 3 hours. The results revealed increased heparin regimens can significantly prolog APTT values (100 U +70 U > 70 U +50 U > 40 U + 30 U, P < 0.01) from the arterial and venous sides of the blood tubing set, and there were no significant differences ( p >0.05, n=5) of the residual dry blood weights within the dialyzer in experiment I. However, many blood clots were found in the chambers of the blood tubing set that was used in one dog with low heparin regimen (40 U + 30 U), no blood clots were observed in the blood tubing set used in both blood flow rate regimens (30 mL/min, 100 mL/min). Nevertheless, higher blood flow rate did reslt in less residual dry blood weight (p<0.01, n=4), though the APTT values (100 mL/min) from the venous side of the blood tubing set were lower significantly than 30 mL/min regimen (p<0.05). Based on the results, we conclude that appropriate heparin dosage and increasing of blood flow rate can reduce clot formation in extracorporeal circulation on hemodialysis in dogs. |