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題 名 | Gut-Independent Tumor Necrosis Factor-Alpha Secretion Induced by Hemorrhagic Shock in Rats=出血性休克時與腸子相關機轉無關之腫瘤壞死因子的分泌 |
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作 者 | 張財旺; 林炳文; | 書刊名 | 中華民國外科醫學會雜誌 |
卷 期 | 30:2 民86.03-04 |
頁 次 | 頁79-85 |
分類號 | 416.123 |
關鍵詞 | 出血性休克; 腫瘤壞死因子; TNF-α; Hemorrhagic shock; Enterectomy; |
語 文 | 英文(English) |
中文摘要 | 本研究旨在使用缺乏腸子的動物模式去探討出血性休克時與腸子無關的腫瘤壞死 因子( TNF- α)的分泌。 實驗組動物先經手術切除大小腸後,再以 Wiggers 模式造成出 血性休克(平均血壓 30-35 mmHg )持續 120 分鐘後再將放出的血打回動物。 對照組動物 則在切除腸子後接受假設性休克。 結果, 實驗組動物在休克期間之平均放血量(平均值± SEM )為 6.83 ± 0.35 mL,約佔血溶液容量之 29.8 ± 1.4 %。 休克後實驗組動物之平 均血壓回復至 79.7 ± 2.84 mmHg (n=17),與對照組( 87.2 ± 2.43 mmHg, n=15 )比較 ,二者沒有顯著差別( p>0.05 )。實驗組動物血中之 TNF- α濃度,以酵素連接免疫吸附 法( ELISA )測量發現,在放血休克後 60 分鐘開始上升( 95.8 ± 32.9 pg/mL, p<0.01 ),而在血打回後 120 分鐘到達尖峰值( 410.2 ± 36.0 pg/mL, p<0.01 )。對照組動物 血中之 TNF- α則在整個實驗過程中都無法測得。 本研究結果發現切除全部大小腸並未能避免出血性休克引致之 TNF- α的分泌;顯示出血性 休克時存有腸子無關 TNF- α分泌機轉。 |
英文摘要 | This study was aimed at investigating hemorrhage-induced tumor necrosis factor- α (TNF- α ) secretion in the animal model lacking the intestines. A Wiggers model of hemorrhagic shock (30-35 mm Hg for 120 minutes) and restoraton of the shed blood was used. After enterectomy, the experimental group and control group animals were subjected to hemorrhagic shock and sham shock, respectively. The average volume (mean ± SEM) of shed blood was 6.83 ± 0.35 mL in experimental animals, which accounts for 29.8 ± 1.4 % of blood volume. After shock, mean arterial pressure (mean ± SEM) recovered to 79.7 ± 2.84 mm Hg in the experimental group (n=17), which was of no significant difference from that of the control group (87.2 ± 2.43 mmHg, n=15; p>0.05). In the experimental group, TNF- α concentrations in systemic circulation, quantitated by enzyme-linked immunosorbent assay, were found to be significantly elevated at 60 minutes (95.8 ± 32.9 pg/mL, p<0.01) post-shock and peak at two hours (410.2 ± 36.0 pg/mL, p<0.001) after restoration of the shed blood. TNF- α molecules remained undetectable in the blood of sham-shock group throughout the experiment. Limulu assay used to detect endotoxins in blood samples showed no detectable endotoxemia in any specimen from each group. Conclusions: It was concluded that removal of the intestines does not prevent hemorrhage-induced TNF- α secretion, implying a gut-unrelated mechanism of TNF- α formation in hemorrhagic shock. |
本系統中英文摘要資訊取自各篇刊載內容。