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題 名 | Tumor Necrosis Factor-α and Interleukin-6 Profiles in Children with Pneumonia=腫瘤壞死因子和介白素在肺炎病童的變化 |
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作 者 | 王壯銘; 湯仁彬; 鐘瑞隆; 黃碧桃; | 書刊名 | 微免與感染雜誌 |
卷 期 | 32:4 1999.12[民88.12] |
頁 次 | 頁233-238 |
分類號 | 417.5351 |
關鍵詞 | 腫瘤壞死因子; 介白素; 肺炎; Interleukin-6; IL-6; Tumor necrosis factor-α; Pneumonia; TNF-α; |
語 文 | 英文(English) |
中文摘要 | 肺炎是最常造成兒童住院的原因之一。TNF-α及IL-6是造成發炎反應的初步因子並且常與感染和非感染的發炎反應有關。我們利用酵素免疫分析法(ELISA)來測量12位細菌性肺炎病人急性期和恢復期,15位呼吸道融合病毒(RSV)肺炎病人和15個健康對照組人的血中TNF-α和IL-6的濃度。實驗結果顯示TNF-α在細病性肺炎病人急性時期的濃度比在恢復期是有意義的升高,也比RSV肺炎病人及健康對照組來得高(p<0.005)。RSV肺炎病人和健康對照組的TNF-α濃度並沒有差異。比較細菌性肺炎病人急性期,恢復期,RSV肺炎病人和健康對照組發現細菌性病人急性期血中IL-6濃度均有意義的高於其他三組(p<0.005),RSV肺炎病人血中的IL-6濃度亦比健康對照來得高(p<0.005)。綜合以上結果,比較細菌性肺炎急性期和恢復期的TNF-α及IL-6的血清濃度的變化,發現血清中早期TNF-α濃度和血清中IL-6濃度可做為細菌性肺炎的一個指標。但需要更多的研究來建立TNF-α和IL-6在診斷上判別預後的可用生。 |
英文摘要 | Pneumonia is a common cause of hospitalization and is associated with high morbidity in children. Tumor necrosis factor- α (TNF-α) and Interleukin-6 (IL-6)are primary mediators of inflammation, and have been implicated in a large number of infectious and non- infectious inflammatory diseases. The serum concentrations of TNF-α and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA) in 27 patients with bacterial pneumonia (n=12) or respiratory syncytial virus (RSV) pneumonia (n-15) and in 15 healthy control subjects. TNF-α concentrations of patients with bacterial pneumonia in acute stage (16.94 ± 5.70 ng/L) were significantly higher than those in convalescent stage (5.80 ± 0.75 ng/L), in patients with RSV pneumonia (5.06 ± 0.44 ng/L) and in healthy control subjects (5.39 ± 0.68 ng/L) (p < 0.005). TNF-α concentrations of patients with RSV pneumonia were not significantly different from those of the control group. IL-6 concentrations of patients with bacterial pneumonia in acute stage (465.94 ± 290.30 ng/L) were significantly higher than those in convalescent stage (22.04 ± 15.08 ng/L), in patients with RSV pneumonia (7.65 ± 2.58 ng/L), and in healthy control subjects (0.84 ± 0.08 ng/L) (p<0.0005). There was significant difference between patients with RSV pneumonia and the healthy control group (P<0.005). In summary, there were significant differences in TNF-α and IL-6 concentrations between acute stage and convalescent stage in patients with bacterial pneumonia, making them useful as markers for bacterial pneumonia. Further studies are needed to establish the potential diagnostic and prognostic value of TNF-α and IL-6. |
本系統中英文摘要資訊取自各篇刊載內容。