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題 名 | Liposomes-Coated Hydroxyapatite and Tricalcium Phosphate Implanted in the Mandibular Bony Defect of Miniature Swine=以微脂粒覆蓋氫氧磷灰石與磷酸三鈣植入迷你豬下顎骨缺損之研究 |
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作 者 | 黃景勝; 劉坤銘; 陳慶長; 何坤炎; 吳逸民; 王俊欽; 鄭裕民; 柯文龍; 劉振聲; 何雅萍; 王英斌; 洪基隆; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 13:4 1997.04[民86.04] |
頁 次 | 頁213-228 |
分類號 | 416.95 |
關鍵詞 | 微脂粒覆蓋氫氧磷灰石; 磷酸三鈣; 迷你豬; 下顎骨缺損; Liposome; Hydroxyapatite; Tricalcium phosphate; |
語 文 | 英文(English) |
中文摘要 | 牙周疾病之症狀包括:牙齦炎、附著結締組織及齒槽骨的喪失。近年來,牙周疾病之治療隨著新的技術與新材料的開發已有相當的進展,然而,對於牙周病造成的骨缺損,在骨組織以及體積恢復,卻仍無十分可靠的修復材料與技術。微脂粒已被證實對類骨質細胞有促進生長用。本實驗將微脂粒覆蓋氫氧磷灰石與磷酸三鈣為植體,植入迷你豬蓋氫氧磷灰石與磷酸三鈣在迷你豬組織內具有良好的生物相容性。在第三週時植體均被緻密的結締織包圍,而第六週時植體旁已經可以見到新的骨質生成;然而跟純粹的氫氧磷灰石與磷酸三鈣植體比較,骨組織的鈣化程度較不完全,而且骨質生長亦較不足。此外將微脂粒混入洋菜膠中植入骨缺損的結果顯示:微脂粒在骨組織中具有良好的生物相容性,在第三週亦被結締組織包圍,在第六週則有骨痂形成,顯示微脂粒確實具有促進骨組織生長的能力。 |
英文摘要 | Hydroxyapatite and tricalcium phosphate have been used as bone implants for some period of time. Now unfortunately, these materials have failed to become the nucleation sites for bone regeneration. We hypothesized that coating hydroxyapatite and tricalcium phosphate with negatively charged liposomes may improve the nucleation process for new bone formation. The present study was designed to test this hypothesis. Experiments were carried out in 15 minature swines’ mandibular angle with artificial bony defects. In each of the swine, the bony defects on one side were implanted with either liposomes coated with hydroxyapatite or liposomes coated with tricalcium phosphate, while the other side served as control. At the end of the third and sixth weeks following the operation, we observed result, took histology and radiographs of the operated area. The results showed that liposomes-coated materials were biocompatible and their clinical endpoint was enhanced. At the end of the third week, the implant material was surrounded by dense connective tissues. At the end of the sixth week, there were new bone formations near the implanted material. In addition, liposomes which were immobilized in agarose gel and implanted in the defects showed new bony bridge formation. These observations suggest that liposomes have the ability in promoting repair of osseous deficiencies. |
本系統中英文摘要資訊取自各篇刊載內容。