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題名 | 臺灣產生藥桶鉤藤(扛香藤)與靈芝之抗脂質過氧化及活性氧清除作用的研究 |
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作者姓名(中文) | 林俊清; | 書刊名 | 中醫藥年報 |
卷期 | 15:2 1997.05[民86.05] |
頁次 | 頁175-258 |
分類號 | 414.33 |
關鍵詞 | 桶鉤藤; 扛香藤; 菊花木; 臺灣鉤藤; 鉤藤; 赤芝; 黑芝; 紫芝; 保肝作用; 抗指質過氧化; 活性氧清除活性; Thang-kau-tin; Mallotus repandus; Bauhinia championii; Uncaria hirsuta; U. rhychophylla; Ganoderma lucidum; G. formo-sanum; G. neo-japonicum; Hepatoprotective effect; Anti-lipid peroxidation; Free radical scavcngcr activity; |
語文 | 中文(Chinese) |
中文摘要 | " 桶鉤藤" 為本省民間藥,具驅風、解熱、鎮痛、止癢、殺蟲等作用,被用治 關節腫痛、風濕痺痛、毒蛇咬傷、外用治跌打損傷, 民間尚廣泛用來治療肝炎、肝硬化。 先前之生藥學研究,作者已經證實本省市售桶鉤藤之基源為:(1) 大戟科 (Euphorbiaceae) 植物扛香藤 Mallotus repandus (Willd.) Muell.-Arg. 的莖部或根、莖之混合物; (2) 豆 科 (Leguminosae) 植物菊花木 Bauhinia championii (Benth.) Benth. 莖部粗大的藤; (3) 茜草科 (Rubiaceae) 植物台灣鉤藤 Uncaria hirsuta Haviland 帶鉤的莖部枝條 (4) 茜草科 (Rubiaceae) 植物鉤藤 U. rhychophylla (Mig.) Jacks. 帶鉤的莖部枝條。為了評 估以上各種市售 " 桶鉤藤 " 的藥理活性, 進行了以 FeCl2 誘發老鼠肝臟均質液脂質過氧 化之藥理學研究,並以 ESR spin trapping 技術評估各種桶鉤藤之活性氧清除作用。 結果 顯示,市售各種 " 桶鉤藤 " 皆其抑制脂質過氧化及活性氧清除活性; 而先前之研究顯示市 售各種 " 桶鉤藤 " 皆具抗炎及保肝作用,綜合以上這些結果,可為 " 桶鉤藤 " 在台灣被 用來當作抗炎及保肝藥物提供科學上的證據。經由生藥學及藥理學之研究,筆者建議以大戰 科植物扛香藤 Ma1lotus repandus (Willd.) Muell.-Arg. 作為 " 桶鉤藤 " 較適當。為進 一步探計其有效成分,進行了扛香藤之各分餾成分之抗氧化活性研究。實驗結果顯示以莖部 的乙酸乙酯層之 superoxide radical scavenger 活性最高: 而莖部及根部的正己烷層則顯 示最強之消除 hydroxyl radica1 活性。 此外為了解明台灣常用市售三種靈芝 G. lucidum , G. formosanum 及 G. neo-japonicum 之保肝活性與抗氧化活性之關係, 作者亦進行以 CC14 誘發急性肝毒性、以 FeCl2 誘發老鼠肝臟均質液脂質過氧化及以 ESR- spintrapping 技術,探討其藥理活性與抗氧化活性之關係。 實驗結果顯示,市售三種靈芝 G. lucidum, G. formosanum 及 G. neo-japonicum 皆能有效抑制因投與 CCl4 所導致之 GOT、 GPT 及 LDH 值上升現象, 亦具抑制脂質過氧化及活性氧清除活性,其中以 G. formosanum 具最佳 之保肝活性及自由基清除活性。 |
英文摘要 | "Thang-kau-tin", a folk medicine of Taiwan, has been used as an insecticide, to stop itching and as remedy for fever, rheumatic arthritis, snake-bite, hepatitis and liver cirrhosis. It has been demonstrated that the origin of "Thang-kau-tin" on Taiwan market is derived from the following species: (1) the stem or the mixture of stem and root of Mallotus repandus ( Willd) Muell.-Arg. (2) the stem ofBauhinia championii (Benth.) Benth. (3) the stem with hooks of Uncaria hirsuta Haviland and (4) the stem with hooks of U. rhynchophylla (Miq.) Jacks. To examine the pharmacological activities of these crude drugs, the following experimental models were employed: FeC12- induced rat liver homogenate lipid peroxidation. Using ESR (electron spin resonance) and spin trapping technique, the free radical scavenger activity of these crude drugs were investigated. The results indicated that the different of "Thang- kau- tin" on Taiwan market showed anti-lipid peroxidation and free radical scavenger activities. It has been reported that "Thang-kau-tin" on Taiwan market also showed anti-inflammatory and hepatoprotective activities. These results provided the scientific basis for the usefulness of "Thang-kau-tin" on Taiwan to be used as anti-inflammatory and hepatoprotective agents. Through pharmacognostical and pharmacological studies, it was suggested that M. repandus should be taken as the name of " Thang-kau-tin". Since M. repandus which has been reported to possess anti- inflammatory and hepatoprotective activities, has the possibility of a scavenging effect on free radicals as one of the mechanisms of action, we investigated the scavenging ability of the fractional extracts from M. repandus by ESR (electron spin resonance) spectrometry using 5, 5-dimethyl-l-pyrroline-Noxide (DMPO) as a spin trap. The ethyl acetate fraction of M. repandus (stem) showed the greatest superoxide radical scavenger activity and the n- hexane fraction of M. repandus (stem as well as root) the greatest hydroxyl radical scavenger activity. There are many kinds of "Reishi" were found in Taiwan market. In order to realize the relationship between hepatoprotective effect and antioxidant effect of three different kinds of "Reishi" on Taiwan market, Ganoderma lucidum, G. formosanum and G. neo-japonicum, the following experimental models were employed: CC14-induced hepatotoxicity in rats, FeC12-induced rat liver homogenate lipid peroxidation and the active oxygen scavenging activity were also investigated by using ESR-spin trapping technique. The results indicated that the levels of glutamic oxaloacetic transaminase (GOT) and lactic dehydrogenase (LDH) in the serum caused by. CC14 were markedly decreased by treatment of water extracts of these three kinds of "Reishi" on Taiwan market. Furthermore, these three kinds of "Reishi" also exhibited antioxidant effect in active oxygen scavenging and lipid peroxidation inhibitory activity. G. formosanum showed the greatest antihepatotoxic activity and the greatest free radical scavenging activity. |
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