查詢結果分析
來源資料
頁籤選單縮合
題 名 | 抗青光眼藥物對結膜下纖維母細胞的影響 |
---|---|
作 者 | 莊文慧; 李世煌; | 書刊名 | 中華民國眼科醫學會雜誌 |
卷 期 | 34:1 1995.03[民84.03] |
頁 次 | 頁27-33 |
分類號 | 416.748 |
關鍵詞 | 青光眼藥物; 結膜; 纖維母細胞; Glaucoma; Conjunctiva; Fibroblast; |
語 文 | 中文(Chinese) |
中文摘要 | 長期使用局部抗青光眼藥物會降低日後青光眼濾過手術(Glaucoma filtering surgery)的成功率,而青光眼濾過手術之成功率與術後結膜下纖維母細胞 之增殖有密切關係。為進一步了解抗青光眼藥物對纖維母細胞的直接影響,我們 測試在不同濃度的Timolol及Pilocarpine作用之下,纖維母細胞生長的情形,另外 以Trypan-blue標定死細胞之方法,進一步測定這些藥物對纖雛母細胞可能的毒性 作用。實驗結果顯示:在任何濃度下,Timolol及Pilocarpine對纖維母細胞都無促進 生長的作用;但Timolol濃度高於0.125、Pilocarpmne濃度高於0.1時,纖維母細胞之 增殖明顯地會受到抑制,藥物濃度越高、浸泡時間越長,抑制作用也越明顯;0.5 Timolol及4Pilocarpmne只須9小時,便開始對細胞產生毒性作用。由這些結果我們 推論:臨床使用的Timolol及Pilocarpmne並不會直接引起結膜下纖維母細胞的增 生,長期點藥引起的結膜、角膜或淚液的改變,可能才是造成濾過手術失敗的主 要原因。 |
英文摘要 | After long-term use of topical antiglaucomamedications, the successful rate of glaucoma filteringsurgery is depressed significantly; this study wasdesigned to investigate the direct effect of antiglaucoma medications on subconjunctival fibroblasts.Different concentrations of tirnolol and pilocarpinewere added into the culture medium of humansubconjunctival fibrblasts. After I or 14 days, cellviability and cell proliferation rate were determinedseperately. The results showed that at clinically usedconcentration both tirnolol and pilocarpine were cytotoxic for subconjunctival fibroblast, cell deathbeing noted 9 hours after drug addition. Cellproliferation was inhibited also by 0.1 pilocarpineor 0.125 timolol. This inhibitory effect becamemore apparent when incubaion time was increased.All of these findings indicate that timolol andpilocarpine all have inhibitory effect on subcon-junctival fibroblast proliferation. The increased cellproliferation after long-term topical antiglaucomamedications must be caused by some indirect effectsof topical medications on conjunctiva. |
本系統中英文摘要資訊取自各篇刊載內容。