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頁籤選單縮合
題名 | 前房液中細胞生長因子之測定 |
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作者姓名(中文) | 李世煌; | 書刊名 | 中華民國眼科醫學會雜誌 |
卷期 | 31:2 1992.06[民81.06] |
頁次 | 頁21-26 |
分類號 | 416.748 |
關鍵詞 | 前房液; 細胞生長; 青光眼濾過手術; 纖維母細胞; 結膜; Aqueous humor; Glaucoma; Fibroblast; Growth modulating factors; |
語文 | 中文(Chinese) |
中文摘要 | 青光眼濾過手術(Glaucomatous filtering surgery)之成功率與術後結膜下纖 維母細胞之反應有密切關係,許多研究結果顯示前房液中含有促進細胞生長之物 質,但也有作者報告前房液含有抑制細胞生長之物質。為更進一步了解前房液對 結膜下纖維母細胞之影響,我們收集白內障患者之前房液,將之加入纖維母細胞 之培養液中,以觀察前房液對細胞吸收�鯨-thymidine之影響;另外以 Chloroform-methanol淬取前房液,將淬取物真空乾燥後,再加入細胞培養液中, 以測定各種成分對纖維母細胞之影響。實驗之結果顯示:前房液能增進纖維母細 胞之生長,濃度愈高細胞生長愈快,但100前房液反而會使細胞脫落死亡。將前 房液短暫加熱,並不會破壞其中影響細胞生長之物質。以Chloroform-methanol淬 取前房液,可自其中分離出促進細胞生長與抑制細胞生長兩種物質,促進細胞生 長物質之作用力可被維他命C部分中和掉。由這些結果,我們推論青光眼術後組 織之反應可能與前房液中此兩種生長調節物質或維他命C之含量有關。 |
英文摘要 | The clinical result of glaucoma filtering surgeryis closely related to the postoperative proliferation of subconjunctival fibroblast. In the past, many studies have shown that aqueous humor has profoundeffect on subconjunctival fibroblast proliferation. By studying the cellular uptake of radioactive thy-midine, we found that aqueous humor can signifi-cantly stimulate the proliferation of subconjunctivalfibroblast; but that 100 aqueous humor can cause some cells to lysis, however. The growth-modulating factors in aqueous humor were found to be quite heat-stable, and these factors could be extracted from aqueous humor by chloroform-methanol mixture. The growth-modulating effects of aqueous humor were well preserved after this extraction. Besides, we also found that ascorbic acid could partially block the growth-stimulating effect of aqueous humor on subconjunctival fibroblast. |
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