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題名 | 維生素C與前房液對結膜下纖維母細胞增殖所扮演的角色 |
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作者姓名(中文) | 李政儀; 李世煌; | 書刊名 | 中華民國眼科醫學會雜誌 |
卷期 | 31:2 1992.06[民81.06] |
頁次 | 頁27-31 |
分類號 | 416.741 |
關鍵詞 | 維生素C; 前房液; 結膜; 纖維母細胞; 細胞增殖; Ascorbic acid; Aqueous humor; Subconjunctival fibroblast; |
語文 | 中文(Chinese) |
中文摘要 | 正常人類之前房液中含有大量維生素C,其其正功能目前仍不清楚。我 們利用體外細胞培養之技術,定量纖維母細胞吸收�鯨-thymidine之能力,證實較 正常前房液濃度低之維生素C(0.55mmole/1)即具有破壞纖維母細胞之功能;而前房 液則同時具有促進與抑制纖維母細胞生長兩種不同之功能;但是將前房液加入含 維生素C之培養液中,前房液促進細胞生長之功能完全被抑制,前房液抑制或殺 死纖維母細胞之功能反而變得較明顯。此結果顯示前房液對纖維母細胞之影響, 可能與其中之維生素C之含量多寡有密切關係存在。 |
英文摘要 | Human aqueous humor has a mysterious effecton the proliferation of subconjunctival fibroblast. Inaddition to salt, amino acid, and protein, aqueoushumor contains a very high concentratin of ascorbicacid. By measuring the H-thymidine uptake bysubconjunctival fibroblast, we found that humanaqueous humor could stimulate fibroblast prolifera-tion at a concentration below 75, and that somefibroblasts were lysed by 100 aqueous humor.Ascorbic acid also lysed cultured subcoi-^^unctival fibroblast significantly at a concentration above 0.55 mmol/1 (nonnal aqueous humor concentration of ascorbic acid is 1.1 mmol/1). When 0.14 mmol/1 of ascorbic acid was added into aqueous humor, the growth stimulating effect of aqueous humor was totally blocked, and its inhibitory effect on fibroblast was enhanced significantly. These results imply that the influence of aqueous humor on subconjunctival fibroblast proliferation may be further modified by the concurrent concentratin of ascorbic acid. |
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