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題名 | 添加異麥芽寡醣管灌配方對於慢性臥床使用呼吸器病患腸道功能及菌相之影響=Effects of Isomaltose Oligosaccharide Supplementation by Tube-feeding on Intestinal Functions and Microflora in Chronic Bedridden Patients on Respirators |
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作者姓名(中文) | 洪若樸; 黃啟訓; 邱文祥; 楊素卿; 趙振瑞; | 書刊名 | 臺灣營養學會雜誌 |
卷期 | 38:3 2013.09[民102.09] |
頁次 | 頁84-97 |
分類號 | 411.38 |
關鍵詞 | 管灌; 呼吸器依賴者; 腸道功能; 異麥芽寡糖; 腸道菌相; Tube-feeding; Respirators; Intestinal functions; Isomaltose-oligosaccharide; IMO; Intestinal microflora; |
語文 | 中文(Chinese) |
中文摘要 | 本研究在探討添加異麥芽寡醣(isomalto-oligosaccharide, IMO)管灌配方對於慢性臥床使用呼吸器依賴者腸道功能及菌相之影響。實驗對象為20位大於45歲以上使用鼻胃灌食者隨機分為兩組各10人,先給予調整灌食配方(Isocal HN+Jevity HN Abbott)一星期後,進行交叉試驗。一組給予添加10公克異麥芽寡醣之灌食配方,另一組則不添加,時間持續4週。接著排空期2週,兩組的灌食配方對調,時間持續4週。血液、糞便樣本則實驗前-1、0、2、4、6、8、10週收集並紀錄腸胃功能特性。檢測血液中血紅素、白蛋白等分析,糞便則分析其重量、含水量、乳酸桿菌數及雙叉桿菌數。結果顯示,添加異麥芽寡醣第4、10週時血紅素、白蛋白、糞便之重量、含水量、乳酸桿菌數及雙叉桿菌數都顯著增加(p<0.05);糞便產氣莢膜梭菌數顯著減少(p<0.05)。因此,常規介入異麥芽寡糖的添加可以改善人類的腸道菌相;即增加腸道有益菌雙叉桿菌與乳酸桿菌並減少產氣莢膜梭菌,有助於排便。 |
英文摘要 | In this study we examined the effects of isomaltose oligosaccharide (IMO) supplementation by tube-feeding on intestinal functions and flora in chronic bedridden patients on respirators. Twenty subjects aged >45 years old undergoing tube feeding were recruited for this randomized crossover study. One week after being given Isocal HN and Jevity HN Abbott formula, 10 subjects were given tube feeding with 10 g IMO supplementation every morning for 4 weeks, and then switched to tube feeding without IMO supplementation for 4 weeks after a 2-week washout period, and this protocol was reversed for the other 10 subjects. Blood and fecal samples were collected 1 week before the experiment, at weeks 0, 2, 4, 6, 8, and 10 for further analyses, and gastrointestinal function was recorded. Results showed that blood hemoglobin, albumin, fecal weight, water content, and amounts of Lactobacillus and Bifidobacterium in the feces significantly increased in subjects given tube feeding with IMO supplementation in weeks 4 and 10 (<0.05). However, the amount of Clostridium perfringens was decreased (<0.05). Therefore, IMO supplementation enhanced the intestinal probiotic Bifidobacterium, increased the amount of Lactobacillus, decreased the amount of Clostridium perfringens, and improved fecal excretion. |
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