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題名 | The Traditional Chinese Medicine, Monascus-Fermented Rice, Prevents Zn Deficiency-Induced Testis and Sperms Injury=傳統中藥紅麴米對鋅缺乏所誘導睪丸及精蟲傷害之保護作用 |
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作 者 | 李保宏; 廖俊旺; 王健行; 潘子明; | 書刊名 | Journal of Food and Drug Analysis |
卷期 | 19:2 2011.06[民100.06] |
頁次 | 頁183-190+241 |
分類號 | 414.5 |
關鍵詞 | 紅麴米; 鋅缺乏; 抗氧化酵素; 睪固酮; 精蟲; Red mold rice; RMR; Zn deficiency; Antioxidant enzymes activity; Testosterone; Sperm; |
語文 | 英文(English) |
英文摘要 | Monascus purpureus is a fungus used in rice fermentation. Monascus-fermented rice is called red-mold rice (RMR) in Taiwan since the fermentation products contain a considerable amount of red pigments. The protective effects of RMR on oxidative stress in the testis and sperm were evaluated in this study. Zn deficiency was induced in rats by feeding them with a Zn-deficient diet for 12 weeks while the control rats were fed with a normal diet. The Zn-deficient rats were then divided into 6 groups, designated as Zn-deficient (ZD), Zn-compensated (ZC), 1R (151 mg RMR/kg), 5R (755 mg RMR/kg), 1R + ZC (1RZ), and 5R + ZC (5RZ). The animals were administered with the mentioned diet (RMR/Zn) for 8 weeks. In the ZD rats, no spermatid cell formation was observed in the seminiferous tubular epithelia, and testis necrosis/atrophy was apparent. However, 5R and 5RZ administration improved testicular antioxidant enzyme activity, elevated serum testosterone levels, and increased sperm number in ZD rats; this treatment also exhibited inhibitory effects on caspase activities and reactive oxygen species (ROS) levels in the ZD rats, suggesting that RMR attenuated ZD-induced oxidative stress and testis apoptosis. The preventive activity against ZD-induced reproductive damage was more apparent in the 1RZ and 5RZ groups than in the ZC group, suggesting that RMR can serve as a supplement in adjuvant therapy for diseases associated with Zn deficiency. |
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