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題名 | Effect of High-Dose Ketoconazole Treatment on Serum Levels of Testosterone and Cortisol in Male Dogs=高劑量Ketoconazole於公犬睪固酮及氫基皮質酮血清值之作用 |
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作者 | 張力天; 馮翰鵬; 茅繼良; 陳鵬文; 莊士德; 鄭豐邦; | 書刊名 | 中華民國獸醫學會雜誌 |
卷期 | 25:4 1999.12[民88.12] |
頁次 | 頁257-261 |
分類號 | 437.27 |
關鍵詞 | 氫基皮質酮; 睪固酮; 公犬; Ketoconazole; Cortisol; Testosterone; Male dogs; |
語文 | 英文(English) |
英文摘要 | Ketoconazole (KCZ), an imidazole antifungal agent, has a characteristics of causing androgen deficiency. This study was undertaken to investigate the effects of KCZ on steroid hormone secretion of adrenal glands and testes in male dogs. Six healthy male dogs were administered with a high dose (30 mg/kg of body weight/day) of KCZ. Serum concentrations of testosterone, cortisol and progesterone were measured using ELISA kits (NEOGEN E ). Serum biochemical values of AST, ALT, ALP and cholesterol were measured. Numbers of spermatozoa were counted after semen collection every other day. High-dose KCZ significantly decreased serum levels of testosterone, cortisol and cholesterol concentrations (P<0.001). While significantly increased progesterone concentrations (P<0.001). However, the serum biochemical values of AST, ALT and ALP were in the normal range. Oligospermia was observed occasionally in each experimental dog. The results showed that high-dose KCZ inhibited conversion of progesterone to testosterone and cortisol in male dogs. |
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