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題 名 | The Treatment of Male Infertility with the Use of Intracytoplasmic Sperm Injection=卵細胞質內精蟲注入法治療男性不孕症 |
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作 者 | 陳宏恩; 黃一勝; 黃建榮; 黃詩嘉; | 書刊名 | 臺灣性學學刊 |
卷 期 | 4:2 1998.09[民87.09] |
頁 次 | 頁63-70 |
分類號 | 415.8616 |
關鍵詞 | 卵細胞質內精蟲注入法; 副睪丸精蟲顯微抽取術; 睪丸精蟲萃取術; Intracytoplasmic sperm injection; Microsurgical epididymal sperm aspiration; Testicular sperm extraction; |
語 文 | 英文(English) |
中文摘要 | 傳統的人工助孕科技,諸如體外受精,受精卵輸卵管植入,胚胎植入術等,長久 以來已被應用於治療男性不孕症,惟效果並非很好。但自 1992 年卵細胞質內精蟲注入法成 功發展之後,對男性不孕症的治療又邁進了一大步。 自 1995 年 7 月至 1996 年 10 月, 共有 23 對夫妻因男性因素導致的不孕來本院求診並接受卵細胞質內精蟲注入法的治療。其 中有 5 位病人為無精蟲症患者,7 位為精蟲過少症, 其餘 11 位精蟲無力症患者中,有一 位患者接受 3 個療程。無精蟲症患者當中,其精蟲之取得有 2 位是靠副睪丸精蟲顯微抽取 術,另外 3 位是靠睪丸精蟲萃取術。結果有 3 位妻子懷孕,懷孕率為 60% ( 3/5 )。精 蟲過少症患者中,有 5 位妻子懷孕,懷孕率為 71.4% ( 5/7 )。 至於精蟲無力症患者, 有 6 位妻子懷孕,懷孕率為 46.2% ( 6/13 )。總懷孕率為 56% ( 14/25 )。總受精率 為 58.6% ( 176/300 )。這樣的結果,對於男性不孕症的治療而言,是相當不錯的成績。 雖然這項新技術的應用仍然有一些問題存在,包括費用昂貴,早產兒機率以及母親之相關併 發症的機率較高等等,但是對於那些因男性因素導致不孕的患者,確實能夠提供相當大的幫 助。 |
英文摘要 | Intracytoplasmic sperm injection (ICSI), which became available in 1992, has been recognized to be most effective and successful modality in the treatment of male factor infertility. From July 1995 to October 1996, there were 23 couples with male factor infertility who received ICSI for pregnancy in this hospital. Among them, 5 patients had azoospermia, 7 patients had oligospermia (sperm count ≦ 10x10��) and 11 patients had asthenospermia (sperm count > 10x10�� but motility <50%). In the azoospermia group, sperms were extracted by the use of microsurgical epididymal sperm aspiration (MESA) in 2 patients and testicular sperm extraction (TESE) in 3 patients. 3 patients got pregnant in 5 IVF cycles (3/5, 60%). In the oligospermia group, 5 patients got pregnant in 7 IVF cycles (5/7, 71.4%). In the remaining group, 6 patients got pregnant in 13 IVF cycles (6/13, 46.2%). The total pregnancy rate was 56% (14/25 cycles). The fertilization rate in 25 treatment cycles was 58.6% (176/300). The preliminary results were encouraging in the treatment of male factor infertility. Intracytoplasmic sperm injection provided better results not only in patients with oligospermia or asthenospermia but also in patients with azoospermia when combined with MESA or TESE. Though the new technologies (MESA/TESE/IVF/ICSI) are expensive with potentially increased rate of premature births, perinatal morbidities and maternal complications, they give hopes for people with male factor infertility who strongly desire their own offspring, especially for those patients with azoospermia. |
本系統中英文摘要資訊取自各篇刊載內容。