查詢結果分析
相關文獻
- Evaluation of Tc-99m (V) DMSA Binding to Human Plasma Proteins
- 白色中國鵝及白羅曼鵝之血清蛋白質量與成分之比較
- Airway Hyperreactivity Modulated by Immunotherapy with Denatured Ovalbumin in Ovalbumin-Sensitized Guinea Pigs
- Relationship between Microalbuminuria, Left Ventricular Mass and Function in Essential Hypertension
- 鹼處理對鴨蛋蛋白成分之影響
- Displacement Effect of Valproate on Bilirubin-Albumin Binding in Human Plasma
- 腎病症候群併用白蛋白和利尿劑之探討
- Proteins of Linseed(Linum Usitatissimum L.), Extraction and Characterization by Electrophoresis
- Effects of Ozone on Ovalbumin Sensitization in Guinea Pigs
- 鎵-67掃描於腫瘤的應用
頁籤選單縮合
題 名 | Evaluation of Tc-99m (V) DMSA Binding to Human Plasma Proteins=Tc-99m (V) DMSA與人類血漿蛋白質作用機轉之研究 |
---|---|
作 者 | 李碧芳; 葉竹來; 邱南津; 劉金昌; 余幸司; 王美惠; 沈立漢; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 24:1 2008.01[民97.01] |
頁 次 | 頁1-9 |
分類號 | 414.93 |
關鍵詞 | 白蛋白; 鎵-67; 血漿蛋白質; 載鐵質; Albumin; Ga-67 citrate; Plasma proteins; Tc-99m (V) DMSA; Transferrin; |
語 文 | 英文(English) |
中文摘要 | 探討 Tc-99m (V) DMSA 於細胞內的作用機轉之前,先針對血液中的血漿與 Tc-99m (V) DMSA 之間的作用機制進行研究;並且以鎵 -67 進行相同的實驗進而加以比較。採用超過濾法、電泳法、膠過濾色層分析法及親合色層分析法進行實驗。於 37oC 時,Tc-99m (V) DMSA 有 45-54% 與血漿蛋白質結合;若於 4oC 時,則有 73-80% 與血漿蛋白質結合。至於鎵-67 與血漿蛋白質結合個別為 43-53% (37oC) 及 75-81% (4oC)。於電泳,Tc-99m (V) DMSA 有 36.05 +/- 2.48% (37oC) 為結合於白蛋白,至於 4oC 時,有 60.04 +/- 1.87% 與白蛋白結合;至於鎵-67 則主要結合於乙型球蛋白 (37oC,34.23 +/- 1.37%;4oC,55.71 +/- 3.69%)。親合色層分析法發現鎵-67 確實是結合於載鐵質,而 Tc-99m (V) DMSA 則否。此實驗證實 Tc-99m (V) DMSA 於血液中,主要與血漿蛋白質結合,其中大部分是與白蛋白加以結合。至於鎵-67 則主要與乙型球蛋白中載鐵質加以結合。 |
英文摘要 | As a critical step toward elucidating the mechanism of localization of Tc-99m (V) dimercaptosuccinic acid (DMSA), we investigated its binding and transport in blood in comparison with Ga-67 citrate. The studies were performed in vitro by incubating Tc-99m (V) DMSA with blood (one sample at 4oC and another at 37oC) to assess its binding to plasma proteins using ultrafiltration, dialysis, electrophoresis, gel filtration chromatography and affinity chromatography. A parallel experiment for determining the blood binding of Ga-67 citrate was performed using the same procedures. Using ultrafiltration, dialysis, electrophoresis and gel filtration chromatography, labeled plasma samples showed that protein binding for Tc-99m (V) DMSA was 45-54% at 37oC and 73-80% at 4oC. The figures for Ga-67 citrate were 43-53% at 37oC and 75-81% at 4oC. Electrophoresis showed that Tc-99m (V) DMSA was mostly bound to plasma albumin (36.05 +/- 2.48% at 37oC and 60.04 +/- 1.87% at 4oC), and that the proportion of Ga-67 radioactivity associated with β-globulin was 34.23 +/- 1.37% at 37oC and 55.71 +/- 3.69% at 4oC. In affinity chromatography experiments, Tc-99m (V) DMSA did not bind to transferrin, unlike Ga-67 citrate. This study demonstrates that, at the radiopharmaceutical tracer level, most Tc-99m (V) DMSA in blood is protein-bound, primarily to albumin, but not to transferrin. In contrast, Ga-67 citrate was bound primarily to transferrin. The knowledge that albumin is the main transport protein of Tc-99m (V) DMSA may contribute to a better understanding of its biodistribution and pharmacokinetics. |
本系統中英文摘要資訊取自各篇刊載內容。