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頁籤選單縮合
題 名 | Dietary Flavonoids Suppress Adipogenesis in 3T3-L1 Preadipocytes=膳食類黃酮可抑制3T3-L1脂肪細胞的分化 |
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作 者 | 簡伯容; 陳盈臻; 呂紹俊; 許輔; | 書刊名 | 藥物食品分析 |
卷 期 | 13:2 2005.06[民94.06] |
頁 次 | 頁168-175+195 |
分類號 | 411.3 |
關鍵詞 | 膳食類黃酮; 3T3-L1脂肪細胞; 肥胖分化; Dietary flavonoids; 3T3-L1 adipocyte; Adipogenic differentiation; |
語 文 | 英文(English) |
中文摘要 | 本研究探討膳食中攝取的類黃酮物質,包括兒茶素 (catechin) 、懈黃素 (quercetin) 、堪非黃酮醇 (kaempferol),對3T3-L1脂肪細胞分化的影響。以類黃酮樣本與MDL分化誘導養液共同處理3T3-L1細胞後第八天,發現類黃酮處理之3T3-L1細胞內的三酸甘油脂累積量顯著低於對照組 (p<0.05) ,兒茶素、檞黃素與堪非黃酮醇 (25-100μM) 分別可減少3T3-L1細胞的胞內三酸甘油脂累積量達54.4%,45.7%與29.9%,同時此抑制作用具劑量效應。此外,利用RT-PCR分析,發現兒茶素、檞黃素與堪非黃酮醇均顯著降低3T3-L1細胞中,與脂肪細胞分化相關的C/EBP-α,APPAR-γ與SREBP-I三種轉錄因子之mRNA表現量,顯示類黃酮兒茶素、檞黃素與堪非黃酮醇可透過降低脂肪細胞分化相關的轉錄因子表現,抑制脂肪細胞的分化,故可能有助於肥胖的預防。 |
英文摘要 | This study examined how dietary flavonoids, including catechin, quercetin and kaempferol, affect the differentiation of 3T3-L1 adipocytes. Eight days following induction for differentiation with MDI-medium and simultaneously with the tested flavonoids (day 8), our study found significantly reduced (p < 0.05) intracellular triacylglycerol accumulations of 3T3-L1 cells. This compared positively against the smaller reduction in accumulation found in the vehicle control. This suppressing effect was found to be dose-dependent, and a 54.4%, 45.7% and 29.9% decrease of triacylglycerol production was observed for catechin, quercetin and kaempferol (25-100µM), respectively. Additionally, RT-PCR assays demonstrated that catechin, quercetin and kaempferol markedly reduced the mRNA expressions of C/EBP-α, PPAR-γ and SREBP-1, which are key transcription-factors for 3T3-L1 adipogenesis. These results suggest that dietary flavonoids suppress 3T3-L1 differentiation by down-regulating adipogenic transcription-factors. Further study recommended to explore the potential health benefits of catechin, quercetin and kaempferol in the control of body weight. |
本系統中英文摘要資訊取自各篇刊載內容。