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題 名 | Effects of Retinoic Acid on Pre-implantation Embryo Development in Mice=維他命A衍生物對老鼠著床前胚胎的影響 |
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作 者 | 黃富仁; 林雅苓; | 書刊名 | 長庚醫學 |
卷 期 | 24:11 2001.11[民90.11] |
頁 次 | 頁681-687 |
分類號 | 417.131 |
關鍵詞 | 維他命A衍生物; 老鼠; 著床前胚胎; 胚胎發育學; Retinoic acid; Mice; Pre-implantaion embryo; Embryology; |
語 文 | 英文(English) |
中文摘要 | 背景:在我們的前期研究中,已顯示過量的維他命A衍生物,作用在老鼠的囊胚期胚胎,會造成著床後胚胎發育的負面影響。此研究將進一步探討維他命A衍生物對著床前胚胎發育的影響。 方法:在此前瞻性動物研究,維他命A衍生物的給予劑量分別為0毫克/公斤、50毫克/公斤、100毫克/公斤三組;給予的時間分為二組,一組在妊娠第一天和第二天早上給予、另一組在妊娠第二天晚上和第三天早上給予。最後在第三天下午收集胚胎觀察並記錄結果。 結果:不同劑量的維他命A衍生物作用在受精卵到桑椹期胚胎以前的時期,並不影響最後發育到囊胚期胚胎的數目和形態。而不同劑量的維他命A衍生物作用在桑椹期胚胎的時期,亦不會影響囊胚期胚胎的數目和形態。 結論:此研究發現過量維他命A衍生物作用在老鼠著床前胚胎發育,並沒有明顯的形態學傷害。 |
英文摘要 | Background: In a previous study we had investigated the effect of in utero retinoic acid (RA) exposure on early post-implantation development at the blastocyst stage before implantation and immediately after implantation to understand the possible roles of RA in embryogenesis. The results showed that excess RA affected early post-implantation embryogenesis adversely. We designed the present study to investigate the effect of in utero RA exposure on pre-implantation embryos. Methods: In the prospective animal study, pregnant female mice received early pre-implantation peanut oil with 50mg/kg t-RA or 100 mg/kg t-RA by oral gavage on the morning of day 1 and 2 or late pre-implantation exposure on the night of day 2 and morning of day 3 of gestation. Mice were sacrificed late in day 3. The number and morphology embryos were recorded. Results: All mice given oral RA were sacrificed on the same day. The mean number of embryos per mouse and the percentage of different embryo stages in the t-RA treated mice administered at early pre-implantation embryo or late pre-implantation embryo stage were not significantly different from the controls. The mean number of embryos per 50 mg/kg mouse and the percentage of expanded blastocysts or early blastocysts/morulas did not differ from controls. In addition, the percentage of expanded blastocysts or early blastocysts/morulas was also not significantly different from the control group in 100 mg/kg late pre-implantation mice. Conclusion: Mouse embryo development may not experience dose related adverse effects from non-physiological RA exposure during pre-implantation. |
本系統中英文摘要資訊取自各篇刊載內容。