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題名 | Optimization of the Separation of 1,1'-Bi-2-Naphthol Enantiomers in Preparative Liquid Chromatography=製備級液相層析分離聯奈酚旋光性異構物的最適化研究 |
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作 者 | 賴世明; 林子欽; 羅榮仁; | 書刊名 | Journal of the Chinese Institute of Chemical Engineers |
卷期 | 31:5 2000.09[民89.09] |
頁次 | 頁507-522 |
分類號 | 460.024 |
關鍵詞 | 液相層析; 聯奈酚旋光性異構物; Enantiomeric separation; Adsorption characteristics; Preparative scale; System performance; Optimization; |
語文 | 英文(English) |
中文摘要 | 本研究探討聯柰酚旋光性異構物於Pirkle D-phenylglycine 型管柱上的製備級層析分離。首先以沖提層析法量測各單成份的吸附平衡與質傳動力參數,再以競爭式的bi-Langmuir模式來描述此雙成份系統的吸附平衡等溫關係,代入平衡-擴散模式並數值求解可以預測層析圖譜,另外利用模式擬合法可以同時估算出bi-Langmuir模式參數。由於此理論模擬的層析圖譜可以合理地預測各種操作條件(移動相組成、流量以及注入量)下的實驗層析圖譜,因此乃利用此理論模式來尋找可以獲得最大產率的最佳操作條件。 |
英文摘要 | The separation of enantiomers of 1-1'-bi-2-naphthol on Pirkle covalent D-phenylglycine columns was investigated on the preparative scale. The adsorption characteristics of each isomer, including the equilibrium and kinetic model parameters, were measured by the elution chromatographic method. The competitive bi-Langmuir model was adopted to correlate the adsorption equilibrium isotherms of the binary mixture. The numerical solution of the equilibriumdispersive model of chromatography was used to predict the band profiles, where the isotherm parameters of the binary model were estimated by a model fitting method. The simulated band profiles can reasonably predict the measured chromatograms for various cases of different operating conditions, e.g. mobile phase composition, flow rate and sample size. The optimum operating conditions for the maximum production rate of either one of the two isomers were then found based on the theoretical model. |
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