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題 名 | Hyperdynamic Circulation in Prehepatic Portal Hypertension: Role of Tumor Necrosis Factor-α=腫瘤壞死因子在肝前性門脈高壓之高血流動力循環所扮演之角色 |
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作 者 | 朱啟仁; 李發耀; 張扶陽; 王聖賢; 林漢傑; 吳淑玲; 戴春菁; 李壽東; | 書刊名 | 中華醫學雜誌 |
卷 期 | 59:3 1997.03[民86.03] |
頁 次 | 頁145-150 |
分類號 | 415.138 |
關鍵詞 | 高血流動力循環; 門脈高壓; 腫瘤壞死因子; Hyperdynamic circulation; Portal hypertension; Tumor necrosis factor-alpha; |
語 文 | 英文(English) |
中文摘要 | 背景:門脈高壓常伴隨著高血流動力循環的產生,其特徵為心輸出量增加及系統性血管阻力降低。腫瘤壞死因子( tumor necrosis factor- �` )是由單核細胞受內毒素,組織傷害或腫瘤細胞之刺激所產生,此種細胞素可激活氧化氮的合成進而導致血管擴張。本研究之目的在探討腫瘤壞死因子是否在門脈結紮老鼠之高血流動力循環的病理生理學中扮演某種角色。 方法:我們以熱稀釋法測量 7 隻門脈結紮老鼠及5隻假開刀老鼠之系統性及門脈血流動力參數。此外用免疫酵素吸附法測量34隻門脈結紮老鼠及16隻假開刀老鼠血中之腫瘤壞死因子濃度。 結果:門脈結紮老鼠與假開刀組相比具有較低之平均動脈壓(109 ± 17 mmHg Vs. 133 ± 12mmHg, p<0.001), 較低之系統性血管阻力( 2.5 ± 0.6 mmHg.ml-1.min.100gBW vs. 4.6 ± 0.88 mmHg . ml-1. min.100gBW, p < 0.001),較高之門脈壓(14 ± 1.9 mmHg Vs. 9 ± 2.1 mmHg, P<0.001)及心輸出指數 47.0 ± 12.1 ml . ml-1.100gBW-1 vs. 29.3 ± 3.5 ml. min-1.100gBW, p<0.001)。此外,門脈結紮老鼠其血中腫瘤死因子濃度較假開刀組為高且具有統計學之意義(13.8 ± 0.9 pg/ml vs. 11.1 ± 0.5 pg/ml, p < 0.05)。 結論:本研究結果發現門脈結紮老鼠血中腫瘤壞死因子濃度昇高且伴隨著有高血流動力循環之產生,顯示腫瘤壞死因子可能在高血流動力循環之產生及維持扮演某種角色。 |
英文摘要 | Background: Portal hypertension is associated with a hyperdynamic circulation characterized by increased cardiac output and reduced systemic vascular resistance. Tumor necrosis factor-alpha (TNF-alpha) is a peptide mediator released by mononuclear cells on activation by endotoxin, tissue injury and malignancy. This cytokine induces vasodilatation by activating nitric oxide synthesis. The aim of this study is to investigate if TNF-alpha is involved in the pathogenesis of hyperdynamic circulation observed in portal vein-ligated (PVL) rats. Methods: Systemic and portal hemo-dynamics were determined in seven PVL and five sham-operated (SHAM) rats using a thermodilution technique. In addition, plasma TNF-alpha concentrations were determined in another 34 PVL and 16 SHAM rats using commercially available enzyme-linked immunosorbent assay. Results: PVL rats had a significantly lower mean arterial pressure (109 +/- 17 mmHg vs. 133 +/- 12 mmHg, p < 0.001) and systemic vascular resistance (2.5 +/- 0.6 mmHg ml-1 min 100g BW vs. 4.6 +/- 0.8 mmHg ml-1 min 100g BW, p < 0.001) accompanied by a significantly higher portal pressure (14 +/- 1.9 mmHg vs. 9 +/- 2.1 mmHg, p < 0.001) and cardiac index (47.0 +/- 12.1 ml min-1 100g BW-1 vs. 29.3 +/- 3.5 ml min-1 100g BW-1, p < 0.001) when compared with SHAM rats. Also, PVL rats had significantly higher plasma levels of TNF-alpha as compared with SHAM rats (13.8 +/- 0.9 pg/ml vs. 11.1 +/- 0.5 pg/ml, p < 0.05). Conclusions: This study suggests that elevated plasma levels of TNF-alpha observed in PVL rats may participate in the development and/or maintenance of the hyperdynamic circulation occurring in prehepatic portal hypertension. |
本系統中英文摘要資訊取自各篇刊載內容。