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頁籤選單縮合
題名 | Sex Differences in Pediatric Systemic Lupus Erythematosus: A Retrospective Analysis of 135 Case=孩童期紅斑性狼瘡的性別差異:135例的回溯性分析 |
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作者 | 羅錦通; 蔡銘哲; 王玲華; 黃妙慈; 楊曜旭; 林于粲; 劉淳菁; 江伯倫; Lo, Jin-ton; Tsai, Ming-jer; Wang, Ling-hua; Huang, Miao-tzu; Yang, Yao-hsu; Lin, Yu-tsan; Liu, Joyce; Chiang, Bor-luen; |
期刊 | 微免與感染雜誌 |
出版日期 | 19990900 |
卷期 | 32:3 1999.09[民88.09] |
頁次 | 頁173-178 |
分類號 | 417.5945 |
語文 | eng |
關鍵詞 | 紅斑性狼瘡; 性別; Systemic lupus erythematosus; Gender; |
中文摘要 | 從1989年到1998年在臺大醫院,135例小於18歲孩童期紅斑性狼獊的病例(24例男 性,111 例女性)的回溯性研究。本篇研究的主要目的是比較兩性在診斷年齡,臨床症狀, 實驗數據及存活率上有何差異。男女比率為 1:4.6,男性的平均診斷年齡為 13.7 歲(範圍 從 8 歲 5 個月到 18 歲), 女性的平均診斷年齡為 13.7 歲(範圍從 6 歲 1 個月到 18 歲),在平均診斷年齡上兩者並無顯著的差異。在評估臨床症狀,及實驗數據方面,我們發 現除了在口腔潰瘍,禿髮及抗 SSA 抗體常見於女性外, 在其他方面,兩者並無顯著的不同 。 我們的 5 年及 10 年累積存活率分別為 80.2 %及 65 %,男性似乎有較好的存活率, 但並未達到統計上的意義。單因素分析顯示對於孩童期紅斑性狼瘡的預後,性別並非一顯著 的影響因子,同時也發現在診斷時有不正常的肌酸肝的個案有較高的死亡率,但進一步作多 因素分析後,並沒有統計上的意義。 |
英文摘要 | A retrospective review of 135 patients with systemic lupus erythematosus (SLE) (24 boys and 111 girls) under age 18 at the National Taiwan University Hospital (NTUH) from 1989 to 1998 was done. The aim of this retrospective study was to compare the differences in the age at diagnosis, clinical, laboratory features and survival among both sexes. The female to male ratio was 4.6:1. The mean age at the time of diagnosis was 13.7 years (range, 8y5m-18y) for male patients and 13.7 years (range, 6y1m-18y) for female patients. There was no significant differences in the mean age of diagnosis between the sexes. It was found that there were no significant differences in the clinical and laboratory features between male and female patients except for the prevalence of oral ulcers, alopecia and anti-SSA antibodies which were more frequent in the female group. The cumulative 5- and 10-year survival rates were 80.2% and 65%, respectively; male patients appeared to have a better survival, yet it did not reach any statistical significance. Univariate analysis showed that gender is not a significant factor on prognosis in pediatric SLE. Although abnormal creatinine was associated with poor mortality, it was not statistically significant on multivariate analysis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。