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題名 | Prevalence of Antimicrobial Resistance among Clinical Isolates of Haemophilus Influenzae in Taiwan=臺灣地區流行性感冒嗜血桿菌臨床分離株之抗藥性盛行率 |
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作者 | 林秀真; 王志堅; 于靜梅; 朱夢麟; Lin, Hsiu-chen; Wang, Chih-chien; Yu, Cheing-mei; Chu, Mong-ling; |
期刊 | 臺灣醫學會雜誌 |
出版日期 | 19990500 |
卷期 | 98:5 1999.05[民88.05] |
頁次 | 頁319-325 |
分類號 | 414.83 |
語文 | eng |
關鍵詞 | 臺灣地區; 流行性感冒; 嗜血桿菌; 抗藥性; Haemophilus influenzae; Antimicrobial resistance; Beta-lactamase; |
英文摘要 | The purpose of this study was to determine the prevalence of resistance to various antimicrobial drugs among Haemophilus influenzae isolates in Taiwan. Two hundred and ninety-six clinical isolates of H. influenzae were prospectively obtained from nine teaching hospitals throughout Taiwan, from June 1994 to April 1995. All isolates were examined for the presence of type b encapsulation and β-lactamase production. Antibiotic susceptibility was determined by means of standard broth microdilution procedures. Twenty-three isolates (7.8%) were type b, and the overall rate of β-lactamase production was 58.1% (172/296). The rates of resistance to antibiotics were 58.1% for ampicillin, 33.8% for trimethoprim-sulfamethoxazole, 20.6% for chloramphenicol, 27% for tetracycline, 6.7% for azithromycin, 3.4% for cefaclor, and 0.3% for cefuroxime. Cefixime, ceftriaxone, and ciprofloxacin were active against all H. influenzae isolates. Thirty (10.1%) of the 296 isolates were resistant to three drugs (ampicillin, chloramphenicol, and tetracycline), 16 of which (5.4%) were resistant to four drugs (ampicillin, chloramphenicol, tetracycline, and trimethoprim-sulfamethoxazole). There was a marked increase in the rates of ampicillin resistance and β-lactamase production among H. influenzae isolates compared with a previous survey in Taiwan conducted 9 years ago. In addition, isolates with multiple drug resistance were also identified. Continued efforts are needed to monitor antibiotic resistance patterns of H. influenzae in the region. |
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