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- Immunogenicity and Safety of Haemophilus Influenzae Type b Conjugate Vaccine (HibTITER) and a Combination Vaccine of Diphtheria, Tetanus, Pertussis and HibTITER (TETRAMUNE) in Two-Month-Old Infants
- Immunogenicity of Haemophilus Influenzae B Conjugate Vaccine (HibTITER) and Safety of HibTITER and a Combination Vaccine of Diphtheria, Tetanus, Pertussis and HibTITER in Infants Two Months of Age: A Preliminary Report
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題 名 | Immunogenicity and Safety of Haemophilus Influenzae Type b Conjugate Vaccine (HibTITER) and a Combination Vaccine of Diphtheria, Tetanus, Pertussis and HibTITER (TETRAMUNE) in Two-Month-Old Infants=白喉、破傷風、百日咳三合一疫苗與b型流行感冒嗜血桿菌結合疫苗混合或分開施打於二個月大嬰兒的效果評估與比較 |
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作 者 | 黃立民; 張碧峰; 李秉穎; 丘秀慧; 蔡秀媛; 李慶雲; | 書刊名 | 微免與感染雜誌 |
卷 期 | 31:3 1998.09[民87.09] |
頁 次 | 頁180-186 |
分類號 | 417.517 |
關鍵詞 | 白喉; 破傷風; 百日咳; 三合一疫苗; b型流行性感冒嗜血桿菌結合疫苗; 嬰兒; Haemophilus influenzae type b; Conjugate vaccine; Immunization; |
語 文 | 英文(English) |
中文摘要 | 為了評估白喉、破傷風、百日咳三合一疫苗與b型流行感冒嗜血桿菌結合疫苗混合 或分開同時施打於二、四、六個月大嬰兒的效果,我們將 93 個嬰兒從兩個月大開始分成兩 組, 分別接受白喉、破傷風、百日咳三合一疫苗與 b 型流行感冒嗜血桿菌結合疫苗混合或 同時分開施打。結果發現接種兩劑後所有的嬰兒的抗體都可大於 0.15 μ g ╱ mL,而超過 90 %嬰兒的抗體可以大於 1.0 μ g ╱ mL。至於施打疫苗後所產生的副作用兩種都差不多 ,主要為發燒和施打部位的局部不適。因此,我們認為白喉、破傷風、百日咳三合一疫苗與 b 型流行感冒嗜血桿菌結合疫苗混合或同時分開施打於二、四、六個月大嬰兒的效果良好且 安全性高。 此外,白喉、破傷風、百日咳三合一疫苗與 b 型流行感冒嗜血桿菌結合疫苗混 合施打可減少嬰兒打針的次數。 |
英文摘要 | A study was undertaken to evaluate the safety and immunogenicity of a combination vaccine (TETRAMUNE) of conjugate Haemophilus influenzae type b (Hib) vaccine (HibTITER) and DTP (Diphtheria, Tetanus and Pertussis) vaccine. A total of 93 healthy children were randomized to receive either TETRAMUNE (combined group), or DTP and HibTITER administered concurrently (separate group) in separate syringes at approximately 2, 4 and 6 months of age in Taiwan. Serologic responses were largely comparable between the two vaccine groups; almost all subjects were seropositive to Hib PRP (polyribosylribitol phosphate) and were protected against diphtheria and tetanus after 2 doses of vaccine and mounted prominent responses to the components of Bordetella pertussis. Subjects in the combined group did not experience more adverse reactions compared with those in the separate group. We concluded that HibTITER was highly immunogenic and safe when administered concurrently with DTP vaccine to Taiwanese children. TETRAMUNE was also safe and immunogenic and might reduce the number of injections to achieve the same protection. |
本系統中英文摘要資訊取自各篇刊載內容。