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題 名 | Safety and Immunogenicity of a Diphtheria, Tetanus, and Acellular Pertussis-Inactivated Poliovirus Vaccine/ Haemophilus Influenzae Type B Combination Vaccine Administered to Taiwanese Infants at 2, 4, and 6 Months of Age=對臺灣嬰兒於2、4、6個月大時接種白喉、破傷風、三成份非細胞性百日咳疫苗、非活性小兒麻痺疫苗(DTaP-IPV)和b型嗜血桿菌疫苗(Hib)混合疫苗的安全性及免疫反應評估 |
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作 者 | 林奏延; 王盈翔; 張鑾英; 邱政洵; 黃玉成; 唐海文; | 書刊名 | 長庚醫學 |
卷 期 | 26:5 2003.05[民92.05] |
頁 次 | 頁315-322 |
分類號 | 418.293 |
關鍵詞 | 白喉; 破傷風; 非細胞性百日咳疫苗; 非活性小兒麻痺疫苗; B型嗜血桿菌疫苗; 副作用; 免疫反應; Diphtheria; Tatanus; Acellular pertussis; Inactivated poliovirus vaccine; Haemophilus influenzae type b; Reactogenicity; Immunogenicity; |
語 文 | 英文(English) |
中文摘要 | 背景:隨著建議接種的疫苗日益增加,更凸顯出兒童對混合疫苗的迫切需要。本研究是針對台灣嬰兒施予白喉、破傷風、三成份非細胞性百日咳疫苗、 非活性小兒麻痺疫苗(DTaP-IPV),和b型嗜血桿菌疫苗(Hib)一起或分開接種的安全性及抗體反應,作評估比較。 方法:共有60位6週至12週大的健康嬰兒參加。一組接受DTaP-IPV和Hib疫苗混合同一針筒內接種,而另一組則DTaP-IPV和Hib疫苗分開於不同部位接種。接種後由父母觀察副作用並詳實記錄於日記本中。於第一劑疫苗接種前及第三劑疫苗接種後一個月,分別收集血清,以評估免疫抗體變化。 結果:相較於分開接種組,DTaP-IPV和Hib疫苗混合接種的副作用並無增加,局部副作用反而減少。接種第三劑後一個月,除了在混合接種組抗小兒麻痺第2型抗體陽轉率(96.4%)較低外,對所有抗原的血清陽轉率皆高達100%。研究亦發現,混合接種組的PRP抗體(8.45[]g/ml)比分開接種組來的低(20.61[]g/ml),但PRP抗體達到保護效果的比率([]0.15[]g/ml或[]1.0[]g/ml),兩組則無差異。 結論:本研究說明利用2、4、6個月時程,DTaP-IPV可以很安全而且有效地和Hib疫苗混合接種,這種混合疫苗是cost-effective,容易被家長及醫師接受,同時可減少兒童接種的痛苦。 |
英文摘要 | Background: Combined vaccines are urgently needed to ensure compliance with the increasing number of recommended vaccines for children. We evaluated the safety and antibody response to a diphtheria, tetanus, and acellular pertussis-inactivated poliovirus vaccine / Haemophilus influenzae type b (DTaP-IPV / Hib) combination vaccine administrated to infants at 2, 4 and 6 months of age. Methods: Sixty healthy infants between 6 and 12 weeks of age were enrolled. One group of vaccines received the DTaP-IPV/Hib in a single injection, while another group concurrently received DTaP-IPV and Hib at separate injection sites. Solicited adverse events were monitored by parental observation and were recorded on a diary card. Levels of serum antibodies to DTaP and polyribosyl-ribitolphosphate-tetanus (PRP-T) antigens were collected before the first vaccine dose and 1 month after the third vaccine dose. Results: The combined-injection group tended to have lower local reactions, and there was no increase in reactogenicity when compared with the separate-injection group. Seroconversion rates were 100% in both groups for all antigens, except for the anti-polio 2 antibody in the combined-injection group (96.4%). The combined-injection group had lower antibody levels of PRP (8.45[]g/ml) than did the separate-injection group (20.61 []g/ml). However, the percentage of vaccines achieving protective levels of antibody to PRP ([]0.15 []g/ml or [] 1.0 []g/ml) was similar in both groups. Conclusions: DTaP-IPV/Hib may be safely and effectively administered to healthy infants, using a 2-, 4-, and 6-month vaccination schedule. This combined vaccine is cost-effective, more acceptable to parents and physicians, and minimizes distress to infants. |
本系統中英文摘要資訊取自各篇刊載內容。