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題 名 | Gd(DTPA-BBA) as a Contrast Agent in Magnetic Resonance Imaging in Rats=新磁振造影對比劑Gd(DTPA-BBA)之大白鼠動物實驗 |
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作 者 | 許瑞昇; 趙垂勳; 王雲銘; 劉金昌; 郭禹廷; 褚佩瑜; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 98:1 1999.01[民88.01] |
頁 次 | 頁49-55 |
分類號 | 414.93 |
關鍵詞 | 新磁振造影對比劑; 大白鼠; 動物實驗; Magnetic resonance imaging; Contrast media; Gd(DTPA-BBA); Hepatobiliary system; |
語 文 | 英文(English) |
英文摘要 | Gadolinium (III)-di(benzyl carbamoylmethyl) diethylenetrinitrilotriacetic acid [Gd(DTPA-BBA)] is a newly developed paramagnetic complex designed for use as a hepatobiliary-specific contrast agent. The purpose of this study was to examine the relaxivity, biodistribution, and magnetic resonance (MR) imaging characteristics of Gd(DTPA-BBA) in rats. Our results showed that the T1 relaxivity of Gd(DTPA-BBA) (3.89 dm□/mmo/s in aqueous solution) was similar to that of Gd(III) diethylenetriamine-pentaacetate [Gd(DTPA)]□ (4.08 dm□/mmol/s) and Gd(III) benzyloxypropionicte-traacetate [Gd(BOPTA)]□ (4.40 dm□/mmol/s). Biodistribution studies indicated that Gd(DTPA-BBA) exhibited hepatobiliary and urinary elimination. In MR imaging studies, Gd(DTPA-BBA) provided biphasic enhancement of normal liver parenchyma, which was characterized by an initial steep increase in enhancement followed by a plateau. The initial relative enhancement (RE%) of the liver, at 1 minute after administration of 0.2 mmol/kg Gd(DTPA-BBA) was 113±19. The plateau RE% of the liver (48±13) occurred within 10 minutes and persisted for at least 60 minutes after injection of the contrast agent. In addition, Gd(DTPA-BBA) provided better RE% of the liver than [Gd(DTPA)]□. The contrast RE% of liver abscess capsules reached a plateau within 5 minutes after injection of 0.1 mmol/kg Gd(DTPA-BBA). Although the hepatic enhancement of Gd(DTPA-BBA) was inferior to that of [Gd(BOPTA)]□, the results suggest that Gd(DTPA-BBA) has potential as an MR contrast agent for nonspecific and hepatobiliary uses. |
本系統中英文摘要資訊取自各篇刊載內容。