查詢結果分析
來源資料
相關文獻
- Effects of Disturbed Flow on Endothelial Cells
- Risk Factors, Endothelial Cell Turnover and Lipid Transport in Atherogenesis
- Responses of Endothelial Cells to Laminar or Disturbed Flow
- Effects of Hyperlipidemia on Aortic Endothelial Cell Turnover and Transendothelial Macromolecular Transport in Cholesterol-Fed Rats
- Role of Endothelial Cell Mitosis in Transendothelial Transport of Low Density Lipoprotein in Hypercholesterolemic and Normal Rabbits
- Effects of Hemodynamic Forces on Vascular Endothelial Cells
- Morphometric Studies on the Fishes of Subfamily Sparinae (Perciformes: Sparidae) from the Coastal Waters of Taiwan
- 角膜內皮細胞形態之電腦分析
- 電解鐵鎳合金粉末
- 由鎘及鉛存在形態來探討萃取法及電動法土壤復育效率
頁籤選單縮合
題名 | Effects of Disturbed Flow on Endothelial Cells=擾流對內皮細胞的影響 |
---|---|
作者 | 張振華; | 書刊名 | 康寧學報 |
卷期 | 1:1 1998.12[民87.12] |
頁次 | 頁201-214 |
分類號 | 415.13 |
關鍵詞 | 動脈硬化; 擾流; 內皮細胞; 形態; 剪力; Atherosclerosis; Disturbed flow; Endothelial cells; Morphology; Shear stress; |
語文 | 英文(English) |
中文摘要 | 動脈硬化的損害區域常出現在動脈系統的彎曲處與分岔處,在這些地方的血流呈 現擾動與不規則的狀態,本實驗之研究目的乃藉著水平層流槽的裝置進行擾流對人類臍靜脈 內皮細胞之影響的體外研究,詳細的剪力分佈與流體結構可藉由處於曲線坐標系的有限體積 法來加以計算。研究結果發現處於低剪力的分隔區之內皮細胞在形態上呈現較圓之趨勢,相 對的,處於高剪力狀態下的內皮細胞之形態則有顯著的被拉長以及沿著流向分佈的趨勢。以 上這些實驗結果可望助於了解活體中的內皮細胞受到擾流影響所造成之反應,進一步增加我 們對動脈硬化成因的認識。 |
英文摘要 | Atherosclerotic lesions tend to localize at curvatures and branches of the arterial system, where the local flow is often disturbed and irregular. The effects of such flow conditions on cultured human umbilical vein endothelial cells (HUVECs) were stuied in vitro by using a horizontal flow channel. Detailed shear stress distributions and flow structures have been computed by using the finite volume method in a general curvilinear coordinate system. HUVECs in the separation areas with low shear stresses were generally rounded in shape. In contrast, the cells under higher shear stresses were significantly elongated and aligned with the flow direction. These in vitro experiments have provided data for the understanding of the in vivo responses of endothelial cells under complex flow environments found in regions of prevalence of atherosclerotic lesions. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。