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題名 | 市售白芷抗氧化活性成分Imperatorin及Isoimperatorin之HPLC分析=The Quantiative Analysis of Antioxidative Principles in Angelica dahurica var. pai chi |
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作者姓名(中文) | 蔡國權; 楊玲玲; 顏焜熒; | 書刊名 | 臺灣科學 |
卷期 | 50:2 1997.12[民86.12] |
頁次 | 頁40-54 |
分類號 | 414.34 |
關鍵詞 | 市售白芷; 抗氧化成分; HPLC成量; Pai-chi; Antioxidative principles; HPLC; |
語文 | 中文(Chinese) |
中文摘要 | 本研究選擇臨床感冒頭痛解表鎮痛-白芷之品質評估,以含量多、安定且具抗氧化 之活性主成分 imperatorin 及 isoimperatorin 為指標, 進行成分之單離、精製、純度試 驗及應用高效液相層析法 (HPLC) 進行市售白芷中藥材之定性及定量分析。高效液相層析條 件如下,層析管柱:LiChrospher 100 RP-18 endcapped (4 mm I.D. × 250 mm); 移動相 :甲醇 - 水 (6:4),流速:1.0 ml/min.;管柱溫度;25 ℃;檢測器:UV 254nm。 回收率 97.2 ∼ 99.2 %。 進行十種市售白芷藥材之定量定性分析, 結果發現市售白芷藥材中 imperatorin 之含量為 0.009 ∼ 0.049 %,而 isoimperatorin 則為 0.013 ∼ 0.055 % ,此結果更顯示若要確保中藥製劑之有效性與安定性,中藥材品質管制乃是首要之工作。 |
英文摘要 | Pai Chi (Angelica dahurica var. pai-chi, Umbelliferae) is used in the treatment as anodyne for frontal headache, supra-orbital neuragia by Chinese herbal doctors. The antioxidative principles were reported. The quantitative analysis method of the major components of Pai-chi is very important work to the quality control on Chinese medicinal industry. Therefore, the novel approaches for determination of antioxidative constituents in Pai-Chi by high performance liquid chromatography will be investigated in this report: reference standards (principles): imperatorin and isoimperatorin; column, LiChrospher 100 RP-18 endcapped (4 mm I.D. × 250 mm); mobile phase, MeOH-H �� O (6:4); flow rate 1.0 ml/min; column temp., 25 ℃; detector, UV 254 nm. The recovery was 97.2-99.2%. 10 kinds of crude drugs were collected from Taipei crude drug's market. The results show that crude drugs contain the imperatorin and isoimperatorin in the range of 0.009-0.049% and 0.013-0.055%, respectively. |
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