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題名 | Chlorpyrifos原體藥劑對天竺鼠之皮膚過敏性=Dermal Sensitization of Technical Chlorpyrifos in Guinea Pigs |
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作者 | 廖俊旺; 蔡三福; 王順成; Liao, J. W.; Tsai, S. F.; Wang, S. C.; |
期刊 | 臺灣畜牧獸醫學會會報 |
出版日期 | 19961200 |
卷期 | 66:4 1996.12[民85.12] |
頁次 | 頁297-305 |
分類號 | 418.1 |
語文 | chi |
關鍵詞 | 皮膚過敏性; 天竺鼠; Chlorpyrifos; Dermal sensitization; Guinea pig; |
中文摘要 | 本試驗依據Guinea Pig Maximiaztion Test (GMPT)法評估由國內合成之 Chlorpyrifos原體藥劑對天竺鼠之皮膚過敏性,並以已知強皮膚過敏藥劑 2,4-dinitro-1-chlorobenzene (DNCB)為陽性對照組。試驗結果顯示由國內合成之 Chlorpyrifos原體藥劑於處理後24及48小時可造成天竺鼠左腰窩皮膚出現中至強度紅斑及 浮腫,72小時後則形成痂皮。1%DNCB陽性的照組處理後病變與Chlorpyrifos原體藥劑相同, 但程度較輕。Chlorpyrifos原體藥劑亦會造成天竺鼠之紅血球總數、血球容積比及血色素減 少現象。依顯微病變觀察結果,Chlorpyrifos原體藥劑與1%DNC均可導致明顯接觸性過敏性 皮膚炎,皮膚病變區域呈現過度角質化,表皮層增厚及水泡形成,真皮層局部出血伴有淋巴 球及少數肥胖細胞聚集於病灶區,同時淋巴結之皮質外圍生發中心(germinal center)有明顯 增殖現象。 |
英文摘要 | Technical Chlorpyrifos was evaluated for sensitizing effect and an well known skin sensitizer "2,4-dinitro-1-chlorobenzene (DNCB)" as a positive control chemical based on Guinea Pig Maximization Test (GMPT). The animals exhibited moderate to severe erythema, edema after 24 and 48 hours, and eschar formation after 72 hours of Technical Chlorpyrifos application. The total counts of red blood cell, hematocrit mean corpuscular volume and hemoglobin decreased in Chlorpyrifos treated animals. The injuries level of Technical Chlorpyrifos are more severe than 1% DNCB> The lesions of allergic contact dermatitis in Technical Chlorpyrifos and 1% DNCB treated animal displayed hyperkeratosis, hyperproliferative epidermis and intraepidermal vesiculation, mainly in lymphocytic and mast cells infiltration, and focal hemorrhage in the dermal layer. Proliferating germinal centers were found in the paracortical area of lymph nodes. |
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