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題 名 | Augmented Effect of Hyperoxia and Tumour Necrosis Factor-α on Leukosequestration and Pro-inflammatory Cytokines Release in Rat Airways=合併暴露於高氧與腫瘤壞死因子對嗜中性白血球之聚集與腫瘤壞死因子和介白質-1β釋放的影響 |
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作 者 | 余志騰; 唐家駿; 黃國雄; 王圳華; 劉劍英; 郭漢彬; 林鴻銓; | 書刊名 | 胸腔醫學 |
卷 期 | 17:4 2002.12[民91.12] |
頁 次 | 頁354-363 |
分類號 | 415.138 |
關鍵詞 | 高氧; 腫瘤壞死因子; 介白質-1β; 嗜中性白血球; Hyperoxia; Tumor necrosis factor-α; Interleukin-1β; Neutrophils; |
語 文 | 英文(English) |
中文摘要 | 背景:儘管氧氣對於血氧過低所導致的呼吸衰竭是一項重要的輔助療法,暴露在高氧氣壓力下可能增加氧氣代謝物的產生、使肺臟傷害惡化。此外、腫瘤壞死因子(TNF-α)也認為與許多肺部和呼吸道的疾病有關,尤其在嗜中性白血球所導致的肺臟傷害。 目的:本研究則是使用動物實驗來探討合併高氧(hyperoxia)與腫瘤壞死因子對嗜中性白血球之聚集(leukosequestration)和前發炎細包激素(pro-inflammatory cytokines)的加強的影響。 方法:實驗採用重量350-500公克的雄性Sprague-Dawley老鼠。以生理食鹽水、腫瘤壞死因子注射入氣管內,或者給予95%氧氣,或者合併給予95%氧氣和腫瘤壞死因子。在呼吸器支持6小時後,實施氣管肺泡灌洗術得到氣管肺泡灌洗液。由haematocytomete計數氣管肺泡灌洗液之細胞總量及其分類。ELISA測驗測量氣管肺泡灌洗液中的腫瘤壞死因子和介白質-1β(lL-1β)的高低。 結果:在氣管肺泡灌洗液中,neutrophils的百分比在暴露於hyperoxia+ NTF-α下,比單獨接受生理食鹽水、腫瘤壞死因子、或者高氧之老鼠,很明顯且有意義的增加(p<0.05)。另外、老鼠在露於hyperoxia+ TNF-α下,也明顯且有意義的增加腫瘤壞死因子和介白質-1β的釋放。而腫瘤壞死因子和介白質-1β的增加,有明顯的相關。另外、neutrophils的百分比,也和腫瘤壞死因子和介白質-1β的增加,呈現明顯的相關性。 結論:合併暴露於高氧與腫瘤壞死因子,對嗜中性白血球之聚集與,腫瘤壞死因子和介白質-1β的釋放,有明顯加強性的影響。 |
英文摘要 | Backgroun: Although oxygen is an important adjunct to therapy in hypoxemic respiratory failure from diverse causes, exposure to high oxygen tension may contribute to exacerbate acute lung injury as a result of increased production of reactive oxygen metabolites. Moreover, tumour necrosis factor-α(TNF-α) is though to be implicated in the many pulmonary and airway diseases, especially in neutrophil mediated lung injury. Objective: To investigate the augmented effects of hyperoxia on TNF-α-induced leukosequestration and pro-inflammatory cytokines release in rat airways. A prospective, randomized, controlled animal study was conducted. Methods: Male Sprague-Dawley rate weighing 350-500g. Were pretreated with intratracheal administration of saline, TNF-αor 95% O2, or both, Bronchoalveolar lavage fluid was recovered from the airway of S-D rats after exposure to 95% O2 and TNF-αfor 6 hours under ventilator support. Cells in lavage fluid were isolated and examined for total and differential counts by haematocytometer. TNF-αand lL-1β in lavage fluid were measured by ELISA. Results: The percentage of neutrophils in BAL fluid was significantly higher in rats exposure to hyperoxia+ TNF-α(29.7±12.5%) compared with rats with hyperoxia (16.3±1.2%), TNF-α(4.2±1.1%) or room air (5.0±1.8%) alone (p<0.05, respectively). Rats exposure to hyperoxia+ TNF-αsignificantly produced higher level of TNF-αand lL-1β, compared with rats with TNF-α, hyperoxia or room air alone. There was a significant correlation between TNF-αand lL-β (p<0.05, rs=0.62, n=20). The total cells and the percentage of neutrophils were also significantly correlated with TNF-αand lL-1β respectively. Conclusions: The combined exposure to hyperoxia and TNF-αcontributes to leukocyte recruitment and subsequently TNF-αand lL-1β release. |
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