頁籤選單縮合
| 題 名 | 乙醯水楊酸甲酯之鎮痛消炎作用 |
|---|---|
| 作 者 | 高惠珍; | 書刊名 | 嘉南學報 |
| 卷 期 | 17 1991.12[民80.12] |
| 頁 次 | 頁76-82 |
| 分類號 | 418.1 |
| 關鍵詞 | 乙醯水; 甲酯; 作用; 消炎; 楊酸; 鎮痛; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 醯水楊酸甲酯(Methyl Acety1 Salicylate,MAS)之用途為保香劑,因其兼具 水楊酸甲醣(Methyl Salicylate)及乙醯水楊酸(ACetylsalicylic acid)之構造,但目前尚 無使用於醫藥治療上之文獻可查詢,本實驗之目的即在探討其藥理作用及急性毒 性。 本實驗利用大白鼠及小白鼠為實驗動物,鎮痛法採取化學刺激法(醋酸法),熱刺 激法(熱板法)及物理刺激法(蹠壓法),其中以醋酸法作用最顯著,於10mg/kg即有 反應,並具劑量依存性(Dose dependent),而Lc�t以Litchhield&Wilcoxor法算出,腹 腔注射為1019mg/kg(900~1153 mg/kg),口服劑量大於1940mg/kg,消炎作用與口服 Acetylsalicylic acid之效果相似,其它有關解熱、抗血小板凝集作用,目前正在探 討中,期能由此研究結果將MAS應用於醫療用途。 |
| 英文摘要 | A study on the possible clinical application of Methyl Acetyl Salicylate (MAS) as anfixative of perfumes was conducted. Analgesic effect to rats and mice were investigated with chemical stimulation method (aceticacid method), heat stimulation method (hot plate method) and physical stimulation method (Pawpressure method). It shows that most prominent effect was observed in the groups tested by aceticacid method (from 10 mg/kg) and it was dose-dependent. Acute toxicity of MAS was investigated also. LD�t values of MAS by intraperitonealapplication was about 1019 mg/kg and by peroral application was high than 1940 mg/kg. Theanti-inflammatory effect of MAS is similiar to Acetylsalicylic acids. Anti-inflammatory and anti-platelet aggregation activities are under investigation. |
本系統中英文摘要資訊取自各篇刊載內容。