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題名 | 傳統中藥方劑解熱效果之研究=The Study of Antipyretic Effect on Traditional Chinese Medicine |
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作者 | 陳關勇; 徐志誠; 陳芳隆; 謝金琅; 陳淑真; 林義宗; 施宏哲; | 書刊名 | 中山醫學雜誌 |
卷期 | 10:1 1999.01[民88.01] |
頁次 | 頁17-28 |
分類號 | 414.5 |
關鍵詞 | 解熱作用; 鎮痛作用; 桂枝湯; 葛根黃芩黃連湯; 川芎茶調散; 銀翹散; 神經化學傳導物質; Anti-pyrexia; Analgesia; Gui zhi tang; G.Z.T.; Ge gen huang lian huang qin tang; G.G.H.L.H.Q.T.; Chung xiong cha tino san; C.X.C.T.S.; Yin qiao san; Y.Q.S.; Neuron chemical transmitter; |
語文 | 中文(Chinese) |
中文摘要 | 本研究旨在探討中藥方劑作用於實驗動物之解熱、鎮痛、抗不安之效果以及自發動之影響, 並測定測定腦內 Noradrenaline(NA),Dopamine(DA),Serotonin(5-HT)等單胺(Monoamine)含量之變化,用以探討藥理作用的機轉。 本實驗使用的中藥方劑:桂枝湯、葛根黃芩黃連湯、川芎茶調散,銀翹散。給藥劑量為250mg/kg、500mg/kg、1000mg/kg分別以口服給藥法(P.O.)投予。實驗結果顯示:桂枝湯、川芎茶調散有良好的解熱作用;葛根黃芩黃連湯,川芎茶調散呈現出鎮痛效果。桂枝湯、川芎茶調散、銀堯散呈現出縮短誘發睡眠的時間;川芎茶調散、銀翹散對睡眠時間呈現有意義的延長;自發運動量的影響試驗中,葛根黃芩黃連湯,桂枝湯均有抑制步行(ambulation)及站立(rearing)作用;腦內單胺含量之測定項目中,桂枝湯給藥群在海馬(Hippocampus)區NA,DA,5-HT 之含量呈現有意義之降低(P<0.05),川芎茶調散於海馬部位NA,DA呈現有意義之降低(P<0.05)。由以上結果得知,本研究中使用的方劑具有良好之解熱、鎮痛及抗不安作用,對自發運動亦無不良影響,經由高速液態層析法之測定可以推論出本研究中的解熱作用是透過海馬區單胺神經元的投射作用影響體溫的調節。 |
英文摘要 | The object of this study is to approach the effect of Chinese medicine on antipyretic, analgesic,anti-anxiety and behavior change in experimental animal. Concomitant determination to the content of monoamine (nor-adrenaline NA, dopamine DA,serotonin 5-HT) in brain proceeds to disclose its mechanism. According to traditional formula, four prescriptions of Chinese medicine are chosen: Gui Zhi Tang (G.Z.T.), Ge Gen Huang Lian Huang Qin Tang (G.G..L.H.Q.T.), Chung Xiong Cha Tino San (C.X.C.T.S.) and Yin Qiao San (Y.Q.S.). With the route via oral, preparations are given to the experimental groups under the dosage of 250mg/kg, 1000mg/kg and 1500mg/kg, respectively. Control group is given distilled water. The results of this investigation reveal (1) every dosage of G.Z.T. and C.X.C.T.S. show good antipyretic effect.(2)dosage of 25 mg/kg, and 1000 mg/kg of G.G.H.L.H.Q.T. and 250 mg/kg C.X.C.T.S. present significance of analgesic effect (p<0.05, p<0.01, p<0.001).(3) every dosage of G.Z.T., C.X.C.T.X., Y.Q.S. present significance of shortening onset time of sleep (p<0.05, p<0.001); every dosage of C.X.C.T.S. and Y.Q.S. present significane of elongating duration time of sleep (p<0.05, p<0.001). (4) dosage of 500 mg/kg of G.G.H.L.H.Q.T. and 1000 mg/kg of G.Z.T. show inhibition of ambulation and rearing in the study of behavior change. (5)results of H.P.L.C. display specific significance that every dosage of G.Z.T. produce significance of lowering content of monoamine in hippocampus (p<0.05) and dosage of 500mg/kg, 1000mg/kg of C.X.C.T.S. present significance of lowering content of NA in hippocampus (p<0.05). According to stated results, investigated prescription reveal good effect of antipyretic, analgesic and behavior change is unmarked. It may support the conclusion under H.P.L.C. finding that antipyretic effect of investigated prescription may influence regulation of body temperature via impulse projection from monoamine neuron in hippocampus to hypothalamus. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。