查詢結果分析
相關文獻
- 靜脈補充精胺酸對亞急性腹膜炎大鼠紅血球及腓腸肌的氧化及硝化壓力之影響
- 全靜脈營養輸液添加精胺酸及N[92b2]-Monomethyl-L-Arginine 對腹膜炎大鼠代謝作用的影響
- Oxidative Chemistry and Chemical Biology of Superoxide, Nitric Oxide and Peroxynitrite
- 外施一氧化氮對甜椒幼苗鹽分逆境之影響
- 全靜脈營養輸液添加精胺酸及N□-Monomethyl-L-Arginine對腹膜炎大鼠免疫反應之影響
- Effects of Zinc Deficiency on Endogenous Antioxidant Enzymes and Lipid Peroxidation in Glomerular Cells of Normal and Five-Sixths Nephrectomized Rats
- 邊緣性葉酸缺乏對F344大白鼠葉酸營養狀態、肝臟抗氧化能力及脂質過氧化傷害之影響
- Lipid Peroxidation and Antioxidative Enzymes in Detached Rice Leaves Exposed to Paraquat
- Synthesis of N変-p-bromophenyl-L-arginine as Potential Nitric Oxide Synthase Inhibitor
- 芝麻油對脂多醣所引發之肝臟傷害的保護
頁籤選單縮合
題 名 | 靜脈補充精胺酸對亞急性腹膜炎大鼠紅血球及腓腸肌的氧化及硝化壓力之影響=Effects of Parenteral Arginine on Oxidative and Nitrosative Stress in Erythrocytes and the Gastrocnemius Muscle of Rats with Subacute Peritonitis |
---|---|
作 者 | 陳雅慧; 李建興; 許立松; 羅慧珍; | 書刊名 | 臺灣營養學會雜誌 |
卷 期 | 38:2 2013.06[民102.06] |
頁 次 | 頁40-49 |
分類號 | 418.2182 |
關鍵詞 | 精胺酸; 靜脈營養; 腹膜炎; 一氧化氮; 脂質過氧化; 抗氧化酵素; Arginine; Parenteral nutrition; Peritonitis; Nitric oxide; Lipid peroxidation; Antioxidant enzymes; |
語 文 | 中文(Chinese) |
中文摘要 | 補充精胺酸有益於心血管疾病,但對發炎性疾病仍無定論。精胺酸於發炎狀況下易造成過量一氧化氮(NO)產生,而引發敗血症。先前研究發現,腹膜炎大鼠靜脈補充總熱量4%的精胺酸,可減緩發炎及增加免疫力;補充高於6%,會減少NO生成,但降低脾臟細胞免疫力。發炎疾病與氧化壓力關係密切,常伴隨肌肉流失現象,故本研究探討靜脈補充精胺酸對腹膜炎大鼠紅血球及腓腸肌氧化及硝化壓力的影響。雄性Wistar大鼠以盲腸穿孔手術誘發亞急性腹膜炎後,給予靜脈補充總熱量1.61、2.85、4.08或6.54%的精胺酸7天,並與未經手術經口餵食的大鼠比較。結果顯示,靜脈補充精胺酸顯著降低腹膜炎增加的肌肉脂質過氧化物含量;補充高於4%總熱量時,顯著改善腹膜炎誘導之血漿亞硝酸及硝酸(NOx)濃度增加及肌肉NOx含量降低,顯著增加血漿及肌肉3-硝化酪胺酸含量,並降低血球穀胱甘肽過氧化物酶活性(p < 0.05)。綜合上述結果可知,靜脈補充低於總熱量4%的精胺酸,可改善亞急性腹膜炎的一氧化氮衡定及肌肉脂質過氧化現象。 |
英文摘要 | Arginine supplementation is beneficial in cardiovascular diseases; however, its use in inflammatory diseases is still controversial because it may induce excess nitric oxide (NO) production leading to septic shock. Previous studies indicated that peritonitic rats parenterally supplemented with approximately 4% of total calories as arginine exhibited attenuated inflammation and increased immunity; when supplemented with > 6% of total calories as arginine, NO production decreased, but splenocytic immunity also significantly decreased. It is known that inflammatory diseases are closely related to oxidative stress and are associated with muscle loss. Therefore, the aim of this study was to investigate the effects of parenteral arginine supplementation on oxidative and nitrosative stress in erythrocytes and the gastrocnemius muscle in rats with peritonitis. Male Wistar rats subjected to cecal puncture-induced subacute peritonitis were infused with parenteral nutrition solutions containing 1.61%, 2.85%, 4.08%, or 6.54% of total calories as arginine for 7 days, and these were compared to rats that did not undergo surgery and were orally fed. Results showed that parenteral arginine significantly decreased the elevated contents of lipid peroxidation products in the muscle. Arginine supplementation at > 4% of total calories significantly improved the peritonitis-induced increase in plasma nitrite/nitrate (NOx) and the decrease in muscle NOx, increased 3-nitrotyrosin in the plasma and muscle, and decreased the activity of glutathione peroxidase in erythrocytes (p < 0.05). These results revealed that supplementation with parenteral arginine at a dose of < 4% of total calories may improve NO homeostasis and lipid peroxidation in the gastrocnemius muscle in subacute peritonitis. |
本系統中英文摘要資訊取自各篇刊載內容。