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題 名 | 探討骨質疏鬆症藥物治療之時間點=Optimal Timing of Medical Intervention for Osteoporosis |
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作 者 | 林峰正; 張維容; 黃亮瑋; 林慶揚; 高木榮; | 書刊名 | 北市醫學雜誌 |
卷 期 | 5:1 2008.02[民97.02] |
頁 次 | 頁46-52 |
分類號 | 415.596 |
關鍵詞 | 骨質疏鬆; 骨質密度; 股骨頸骨折; 股骨轉子間骨折; 脊椎骨折; Osteoporosis; Bone mineral density; Femoral neck fracture; Intertrochanteric fracture; Vertebral fracture; |
語 文 | 中文(Chinese) |
中文摘要 | 目的:在已開發國家,每年因骨質疏鬆導致骨折的發病率已超過心臟病與中風等疾病,且骨折導致的失能狀況並不亞於腦梗塞,顯見骨質疏鬆的社會成本問題相當值得重視。本研究目的係針對骨質密度檢測值分析,期能找出藥物介入的適當時機,以減緩後續可能發生骨折的機率。方法:本研究收集2005年元月至2006年10月間,因股骨頸骨折、股骨轉子間骨折或脊椎骨折而住院治療或接受門診就醫的65歲以上女性患者DXA檢測之骨質密度T值,比較其與對照組-門診非骨折患者二者間T值的差異。結果:資料分析發現T值與年齡為負相關,隨著年齡增長,T值有相對惡化現象,骨折患者的T值較未發生骨折的同齡者顯著偏低。且對照組之年齡與T值相關係數不若研究組顯著,顯示骨密度隨著年齡衰退現象應有其他人為介入的可控因素可緩解,但若未能適時減緩T值惡化速度,則骨折發生機率將隨之升高。同時研究組T值<-2.5的比率達74.4%,對照組僅14.2%,發生骨折的相對危險性(odds ratios)為5.24倍;若改以T值<-3.5為比較標準,研究組個案數達57.7%,較之對照組的2%,其發生骨折的相對危險性高達28倍。結論:綜合研究結果並考量醫療資源的有效利用問題,藥物治療的適當時機建議以T值-3.5為藥物治療的參考底限。 |
英文摘要 | Background & Purpose: In developed countries, the morbidity of fractures caused by osteoporosis has surpassed that of heart disease and stroke; moreover, the disability caused by fractures is no less than by cerebral infarction. Therefore, it is worthwhile to determine the magnitude of the social cost of osteoporosis. The purpose of this study was to analyze bone mineral density data in the hope of finding the appropriate timing for intervention with medications, so as to reduce the probability of corresponding fractures. Methods: BMD T-score data measured by DXA was collected from female patients greater than 65 years of age who were admitted to the hospital or visited the OPD for femoral neck, intertrochanteric, or vertebral fractures between January 2005 and October 2006 in order to determine the difference in T-scores as compared with a control group (non-fracture OPD patients). Results: T-scores had a negative correlation with age. T-scores decreased with age and the T-scores of fracture patients were significantly lower than non-fracture patients at the same age. Furthermore, the correlation coefficient of age and T-scores in the control group was not as significant as in the study group, which suggests that the problem of BMD decreasing with age could be relieved by interventions which served as controllable factors. However, if the decrease in BMD could not be reduced in a timely manner, the probability of fractures would increase. Of the patients in the study group, 74.4% had a T-scores < -2.5 as compared with 14.2% in the control group. The odds ratio for fractures was 5.24. If the comparison standard was changed to a T-scores of < -3.5, 57.7% of patients in the study group would have been included as compared with 2% in the control group; the corresponding odds ratio for fracture would be 28. Conclusion: After summarizing the study results and considering the problem of effective usage of medical resources, it is recommended that a T-scores of -3.5 is the minimum limit for drug treatment. |
本系統中英文摘要資訊取自各篇刊載內容。