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題 名 | Lack of Associations between Several Polymorphisms in Cytokine Genes and the Risk of Chronic Obstructive Pulmonary Diseases in Taiwan=某些細胞激素基因多型性與發生慢性阻塞性肺病之危險性缺乏相關性 |
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作 者 | 謝孟軒; 鍾飲文; 黃吉志; 李建宏; 何啟功; 余明隆; 黃洽鑚; 李純瑩; 吳明蒼; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 24:3 2008.03[民97.03] |
頁 次 | 頁126-137 |
分類號 | 415.428 |
關鍵詞 | 慢性阻塞性肺病; 白介素; 抽菸; 腫瘤壞死因子; COPD; Interleukin; Smoking; Tumor necrosis factor; |
語 文 | 英文(English) |
中文摘要 | 細胞激素 (cytokine) 相關的發炎反應是慢性阻塞性肺病 (chronic obstructive pulmonary disease,COPD) 的致病重要機制,而基因因素或許對於慢性阻塞性肺病的病程發展扮演了重要的角色。本研究的目標是研究在台灣,細胞激素,如 TNF (腫瘤壞死因子)-α(-308),TNF-α(+489),IL (介白素)-1β(-31),IL-1 RN (白介素1受體拮抗劑) 以及 IL-6(-174) 的基因多型性 (genetic polymorphism),和慢性阻塞性肺病之間的相關性。本研究的對象為自 1999 年到 2004 年間的 30 位慢性阻塞性肺病之患者,64 位有慢性阻塞性肺病風險之族群,以及 115 位非慢性阻塞性肺病的對照者。基因的 DNA 由聚合酶鏈反應 (polymerase chain reaction,PCR) 以及限制片段長度多態 (restriction enzyme fragment length polymorphism,RFLP) 方法來分析。在本研究中,各基因型的頻率在病例組和對照組分別為:G/G 在 TNF-α(-308) 為 76.7% 和 83.5%,G/G 在 TNF-α(+489) 為 76.7% 和 68.7%,C/T 在 IL-1β(-31) 為 60.0% 和 55.7%,4R/4R 在 IL-1 RN 和 80.0% 和 86.1%,以及 G/G 在 IL-6(-174) 為 100.1% 和 98.3%。對於慢性阻塞性肺病而言,慢性阻塞性肺病患者和對照組中,其各細胞激素的基因多型性的對偶基因和基因型的分布比例並無明顯差別。此外,在台灣,各細胞激素的基因多型性和慢性阻塞性肺病,包括其不同的亞型,和有抽菸者以及肺功能測試結果並無相關性。抽菸仍然為慢性阻塞性肺病重要的致病因素。 |
英文摘要 | Cytokine-induced inflammation is the predominant underlying mechanism in chronic obstructive pulmonary disease (COPD). Genetic factors may play a pivotal role in the development of this disease. This study looked at the relationship between COPD and genetic polymorphisms in the genes encoding some of these cytokines in a Taiwanese population. The genetic polymorphisms examined in this study were tumor necrosis factor (TNF)-α(-308), TNF-α(+489), interleukin(IL)-1β(-31), interleukin-1 receptor antagonist (IL-1 RN), and IL-6(-174). In total, 30 patients with COPD, 64 subjects at risk of COPD and 115 controls were recruited to the study between 1999 and 2003. DNA was collected from these subjects and analyzed by polymerase chain reaction with sequence-specific primers and restriction enzyme fragment length polymorphism analysis. The frequencies of cytokine genotypes in COPD cases and controls, respectively, were as follows: for G/G in TNF-α(-308), 76.7% and 83.5%; for G/G in TNF-α(+489), 76.7% and 68.7%; for C/T in IL-1β(-31), 60.0% and 55.7%; for 4R/4R in IL-1 RN, 80.0% and 86.1%; and for G/G in IL-6(-174), 100.1% and 98.3%. There was no difference in the distribution of the frequencies of these genotypes and alleles between COPD cases and controls. Moreover, no association was found between these genetic polymorphisms in cytokines and COPD (regardless of COPD subtypes) with respect to cigarette smoking or pulmonary function tests. Despite this, smoking is still an important risk factor for developing COPD. |
本系統中英文摘要資訊取自各篇刊載內容。