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題 名 | 黃芩有效成分對脂多醣體所誘發之急性腎絲球腎炎動物模式之療效評估=A Study of Therapeutic Effect of Huang Qui in Animal Model of Lipopolysaccaride Induced Acute Glomerulonephrities |
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作 者 | 周志中; | 書刊名 | 中醫藥年報 |
卷 期 | 25:1 2007.10[民96.10] |
頁 次 | 頁287-306 |
專 輯 | 中醫藥療效評估之研究 |
分類號 | 418.5 |
關鍵詞 | 黃芩; 脂多醣體; 腎絲球腎炎; |
語 文 | 中文(Chinese) |
中文摘要 | 敗血性休克具危險性的疾病,常伴隨著多重器官的發言感染。臨床上治療腎臟疾病的漢方多用於改善浮腫、尿不利、煩渴等,而中藥黃芩(Scutellaria baicalensis GEORGI)之主要黃酮成份,已知具有多種藥理及抗發炎活性。故本研究目的為在評估黃芩抽出物對此腎炎模式是否具有療效及進一步研究其可能作用機轉。 腎絲球腎炎將6-8週C57BL/6J鼠,每日由腹腔注射脂多醣(lipopolysaccharide, LPS 4.8mg/kg/day),連續注射14日誘發小鼠產生病變後,實驗組小鼠以口服投予黃芩(150mg/kg),一天一次連續14天,而對照組則給予蒸餾水。 經由檢測尿蛋白含量與血清中肌酸酐及尿素氮值,來評估小鼠腎功能,同時利用H&E觀察病理組織改變和以免疫組織化學染色法,評估腎臟組織誘發型一氧化氮合成酶(inducible nitric oxide synthesis, iNOS)、第二型環氧化酶(cyclooxygenases-2, COX-2)的表現。 實驗結果顯示,以腹腔注射脂多醣後對照組老鼠的尿蛋白、血清中肌酸酐及尿素氮值皆明顯增加,並觀察到腎絲球肥大及增生、新月體的形成、腎間質細胞浸潤。但給予黃芩後血清肌酸酐、尿素氮及血中亞硝酸鹽/硝酸鹽(nitrite/nitrate)濃度顯著降低,尿液中的8iso-PGF₂α的濃度變化降低,其為脂質過氧化物的特殊指標。由病理組織切片中,觀測到腎組織病變及嗜中性白血球的浸潤程度明顯減少和腎組織的iNOS、COX-2的表現也明顯降低。 由以上結果顯示,口服黃芩治療可明顯改善由脂多醣所誘發的老鼠腎絲球腎炎病變及腎功能衰退,其機轉可能與降低iNOX及COX-2的表現及減少自由基的生成有關,期望藉由本研究對未來治療腎絲球腎炎之藥物研發提供一有價值的訊息。 |
英文摘要 | Septic shock often accompanied by nephritis has hight mortality. Scutellaria baicalensis GEORGI (SB) (Huang Qui) has been used in Traditional Chinese Medicine for thousands of years in many illnesses and diseases. Many therapeutic effects of SB have been reported includeing anti-inflammatory, anti-bacterial and hepatoprotective activities. The aim of this study was to investigate whether the extracts of Huang Qui have beneficial effect in lipopolysaccharide (LPS)-induced glomerulonehritis (GN) and further evaluate the possible mechanisms involved. First, C57BL/6J mice were injected with LPS (4.8mg/kg/day, i.p.) for 2 weeks. Then, the water extract of SB (150mg/kg/day, p.o.) was administrated for 2 weeks in LPS-induced glomrerulnephritis mice. Our results showed that treatment with extract of SB significantly inhibited the serum blood urea nitrogen (BUN), serum creatinine (SCr), urine protein, nitrite/nitrate, and urine 8-iso-PGF₂α levels compared with that of LPS-injected alone mice. Similarly, the histological examination also showed a lower cellular proliferation in glomeruli, and neutrophil infiltration. Immunohistochemistry data also showed have demonstrated that the expression of inducible nitric oxide synthesis (iNOS), and cyclooxygenases-2 (COX-2) in glomeruli were lower in SB-treated mice. The results indicated that the extract of SB significantly improved the renal function in LPS-treated mice. Furthermore, the inhibition of ROS formation, iNOS and COX-2 expression may be involved in its anti-inflammatory effect. |
本系統中英文摘要資訊取自各篇刊載內容。