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題名 | 新引進藥用植物VUKA (Mondia whitei L.) 對小鼠餵飼之安全性評估=Safety Evaluation of Feeding a Newly Introduced Medicinal Plant VUKA(Mondia whitei L.) to Mice |
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作者 | 郭肇凱; 張隆仁; 陳榮五; 廖俊旺; Kuo, Xhao-kai; Chang, Long-zen; Chen, Yung-wu; Liao, Jiunn-wang; |
期刊 | 臺中區農業改良場研究彙報 |
出版日期 | 20060600 |
卷期 | 91 民95.06 |
頁次 | 頁21-29 |
分類號 | 434.92 |
語文 | chi |
關鍵詞 | 急性毒性; 半致死劑量; VUKA; Mondia whitei; Acute toxicity; Semi-mortality; LD[9274]; |
中文摘要 | 為探討VUKA (Mondia whitei L.) 使用之安全性,以水萃凍乾樣品對小鼠(ICR 品系)進行口服急毒性試驗,測試劑量為15 g/kg body weight ,投予後連續觀察14天。試驗期間全部鼠隻均無死亡,顯示VUKA 水萃凍乾樣品對小鼠口服急毒性之半致死劑量(LD50)每公斤大於15 g ,且處理組之腦、心、肝、腎、脾及胸腺等重要臟器,均無因試驗物質引起肉眼及組織病理變化;血液學檢測中之白血球數、紅血球數、血紅素、血球容積比、平均紅血球體積、平均血紅素、平均血紅素濃度及血小板等相較於對照組均無影響(p>0.05);血清生化檢測中之麩氨酸氨基轉氨酶、麩氨酸丙酸轉氨酶與肌氨酸等相較於對照組亦沒有影響(p>0.05) 。 |
英文摘要 | For the purpose to investigate the safety of utilizing VUKA (Mondia whitei L.), we processed the acute oral toxicity test in ICR mice. There was no mouse dead after given with VUKA extracts during the time course, so the LD50 of water-extracted and freeze-dried powder of VUKA was estimated over 15 g/kg body weight for mice. No significant lesions of brain, heart, liver, kidney, spleen and thymus were found at gross and histopathological observation in the treated mice. Hematological parameters included of WBC, RBC, HGB, HCT, MCV, MCH, MCHC and PLT values were as normal as control. Besides, serum biochemistry changes in liver and renal function included of ALT, AST and creatinine values had no significant difference (p>0.05) with control. |
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