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來源資料
相關文獻
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頁籤選單縮合
題 名 | 天疱瘡--129個病例的臨床分析=Pemphigus--Clinical Analysis of 129 Cases |
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作 者 | 游可任; 楊麗珍; 官裕宗; 何信君; 洪宏翔; | 書刊名 | 中華皮膚科醫學雜誌 |
卷 期 | 25:2 2007.06[民96.06] |
頁 次 | 頁95-102 |
分類號 | 415.765 |
關鍵詞 | 天疱瘡; 自體免疫; 水疱病; Pemphigus; Glucosteroids; Cyclophosphamide; IVIG; |
語 文 | 中文(Chinese) |
中文摘要 | 天疱瘡是種慢性的自體免疫水疱病。若沒有經過適當的治療可能會致命。我們回顧性收集自1998至2005年共129個在長庚醫院診斷及追蹤治療的病人。平均年紀為52.6歲,女男比是1.15:1。女性病人明顯較男性病人年輕(p=0.012)。其中72%是尋常性天疱瘡,20%是落葉性天疱瘡,4%是伴腫瘤性天疱瘡,2%是增殖性天疱瘡,1%是紅斑性天疱瘡,1%是IgA天疱瘡。在尋常性天疱瘡中只有黏膜表現的佔11%,只有皮膚表現的佔40%,皮膚黏膜皆有表現的佔49疱。間接免疫螢光抗體濃度在皮膚黏膜皆表現的尋常性天疱瘡病人明顯比只侵舊巳皮膚或黏膜的尋常性天疱瘡病人高(p=0.002, p=0.019)。併發症機率有57%。包括感染(皮真菌病、白色念珠球菌感染、續發性細菌感染、單純庖疹/帶狀疱疹、疣、泌尿道感染、肺結核、肺部土壤絲菌病),痤瘡/毛囊炎,低白蛋白血症,低血鉀症,高血糖症,腸胃道問題(腸胃不適、消化性潰瘍、上消化道出血),Cushing's徵候群,骨質疏鬆/骨質減少,類固醇性肝炎,類固醇性肌炎,白內障,精神病,股骨頭缺血性壞死,和慢性病毒性肝炎的肝指數上升。在129個病人中有23個曾入院做進一步治療。分析住院病人的臨床治療反應,我們認為高劑量類固醇效用應和脈衝療法效果等級相同,並提出我們目前治療天疱瘡的準則。 |
英文摘要 | Pemphigus is a chronic autoimmune bullous disease. It could be life-threatening if not treated appropriately. We retrospectively enrolled 129 cases diagnosed and treated at CGMH form 1998 to 2005. The mean age at onset was 52.6 years with a female to male ratio of 1.15:1. Female patients were significantly younger than male patients (p=0.012). The frequency of pemphigus was 72%(94) in pemphigus vulgaris, 20%(26) in pemphigus foliaceus, 4%(5) in paraneoplastic pemphigus, 2%(2) in pemphigus vegetants, 1%(1) in pemphigus erythematosus and 1%(1) in IgA pemphigus repectively. In pemphigus vulgaris, mucosal involvement alone was observed in 11%, cutaneous involvement alone in 40% and both in 49%. Indirect immunofluorescence antibody titer of mucocutaneous type pemphigus vulgaris was significantly higher than that of either mucosal or cutaneous type pemphigus vulgaris (p=0.002, p=0.019). Complication rate was 57%. These included infections (dermatophytosis, candidiasis, bacterial infection, HSV/HZV, warts, UTI, pulmonary tuberculosis and pulmonary nocardiosis), acne/folliculitis, hypoalbuminemia, hypokalemia, hyperglycemia, GI problem (GI upset/PU/UGI bleeding), Cushing's syndrome, osteroporosis/osteopenia, steroid-induced hepatitis, steroid-induced myopathy, cataract, psychosis, avascular necrosis of femorus head and elevated liver enzymes in chronic viral hepatitis. Of 129 patients, there were 23 patients hospitalized for further treatment. Analyzing the response of admitted patients, we suggested that high dose steroid has the same weight as pulse therapy in the treatment of pemphigus. And we present our recent treatment protocol of pemphigus. |
本系統中英文摘要資訊取自各篇刊載內容。