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頁籤選單縮合
題名 | Correlations between Weight Changes and Lipid Profile Changes in Schizophrenic Patients after Antipsychotics Therapy=精神分裂症病人在使用抗精神病藥物後其體重變化與脂質變化之相關性 |
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作者 | 黃條來; 盧俊源; Huang, Tiao-lai; Lu, Chun-yuan; |
期刊 | 長庚醫學 |
出版日期 | 20070100、20070200 |
卷期 | 30:1 2007.01-02[民96.01-02] |
頁次 | 頁26-32 |
分類號 | 418.21 |
語文 | eng |
關鍵詞 | 精神分裂症; 膽固醇; 脂質; Antipsychotics; Cholesterol; Lipid; Obesity; Schizophrenia; Weight change; |
中文摘要 | 背景:吾等先前的研究指出精神分裂症病人在3星期內即可發生脂質異常。而在此研究中我們將進一步調查在這短期間內體重變化與脂質變化之相關性。 方法:在一年的期間內,研究個案的年齡、身體指數、使用的抗精神病藥物、治療3星期前後的空腹的脂質濃度。使用的抗精神病藥物包括haloperidol, loxapine, sulpiride, olanzapine, risperidone與clozapine。 結果:共有97個精神分裂症病人加入此研究。我們發現大部分的抗精神病藥物在3星期內皆會引起體重增加。而線性迴歸的統計分析更指出使用clozapine的病人其體重變化與高密度脂蛋白濃度的改變量有顯著的負相關。但服用其他抗精神藥物與其他脂質成分之間並無顯著的相關性。 結論:這研究成果顯示大部分的抗精神病藥物在3星期內皆會引起體重增加,且使用clozapine的病人其體重變化與高密度脂蛋白濃度的改變量有顯著的負相關。然仍需加大個案數以證實此結果。 |
英文摘要 | Background: In our previous study, we had identified strong associations between dyslipidemia and acute-phase schizophrenia during the 3-week study period. In this study, we further investigated the correlations between weight changes and lipid changes during this short period in Taiwan. Methods: During a 1-year period, the data of age, body mass index, antipsychotic drugs and fasting blood samples for serum lipid profiles were collected at baseline and endpoint of 3 weeks. The antipsychotic drugs used include haloperidol, loxapine, sulpiride, olanzapine, risperidone, and clozapine. Results: A total of 97 schizophrenia patients were enrolled in this study. The authors found that most antipsychotic drugs showed increased weight changes in Taiwanese patients. Using linear regression, the authors also found that the weight changes in patients taking clozapine had significantly negative correlation with HDL changes during the 3-week study period. However, no significant correlations between weight changes and lipid changes were noted in patients using other antipsychotic drugs. Conclusions: The results of this study showed that most antipsychotic drugs showed increased weight changes and schizophrenia patients using clozapine might have negative correlations between weight changes and HDL changes during a very short period. However, due to the limitation of the sample size, larger samples are needed to prove the results after controlling confounding factors. |
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