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題名 | A Comparative Study of Three Fecal Occult Blood Tests in Upper Gastrointestinal Bleeding=三種糞便潛血反應試驗於上腸胃道出血病例之比較 |
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作者 | 江建華; 鄭貞英; 王文明; 鄭彬紘; 徐婉婷; 陳百薰; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 22:5 民95.05 |
頁次 | 頁223-228 |
分類號 | 415.5 |
關鍵詞 | 糞便潛血反應試驗; 免疫色層分析法; 血紅素; 上消化道出血; Fecal occult blood test; Immunochromatography; Hemoglobin; Transferrin; Upper gastrointestinal bleeding; |
語文 | 英文(English) |
中文摘要 | 本研究之目的在於:評估三種糞便潛血反應試驗:化學法 o-toluidine,免疫化學法 QC-Hemodia 以及能同時檢測人類血紅素及 transferrin 之免疫色層分析法 Quick Chaser Occult Blood (QCOB) 在上腸胃道出血病例之表現。吾人收集住院於高雄醫學大學附設醫院腸胃內科連續 48 個經胃內視鏡診斷為上腸胃道出血病例之 48 個糞便檢體,經排除掉明顯黑色及鮮血糞便檢體者。結果顯示:QCOB 試驗有最高之糞便潛血陽性率 68.8% (33/48)。QCOB 試驗此 68.8% 陽性率均較 QC-Hemodia 試驗及 o-toluidine 試驗者為高 (p < 0.025,p < 0.01)。上腸胃道出血病例中之胃及十二指腸潰瘍群 QCOB 試驗陽性率 68.6% 較 o-toluidine 試驗者 34.3% 為高 (p < 0.01)。吾人亦發現無任何糞便檢體 o-toluidine 及 QC-Hemodia 試驗陽性而 QCOB 試驗陰性者。本研究結果顯示 QCOB 試驗比 QC-Hemodia 試驗有較高之潛血反應陽性率。對上消化道出血病例,QCOB 試驗比起其他兩種檢驗在糞便潛血反應試驗上有較好的表現。 |
英文摘要 | The purpose of this study was to evaluate the performance characteristics of three fecal occult blood tests (FOBTs): the chemical o-toluidine test, the immunochemical OC-Hemodia test, and the immunochromatographic Quick Chaser Occult Blood (QCOB) test, which detect human hemoglobin and transferrin simultaneously in cases of upper gastrointestinal (GI) bleeding. Included were 48 FOBT specimens in 48 consecutive admission cases of upper GI bleeding (endoscopy confirmed). We excluded those fecal specimens with an obvious tarry and bloody appearance. The QCOB test revealed the highest positive rates of 33/48 (68.8%), and significantly higher positive rates than that of the OC-Hemodia test and o-toluidine test (p < 0.025 and < 0.01, respectively). In the patient group with upper GI bleeding due to gastric and duodenal ulcers, the QCOB test had higher positive rates (68.6%) than did the o-toluidine test (34.3%) (p < 0.01). There was no fecal specimen that was positive for the o-toluidine test or OC-Hemodia test and was negative for the QCOB test. Our results reveal that the QCOB test has significantly higher positive rates of fecal occult blood than either the OC-Hemodia test or o-toluidine test. The QCOB test is better than the other two tests for detecting occult blood in patients with upper GI bleeding. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。