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題 名 | Studies on Fetal Hemoglobin and Gamma Globin Gene Triplication in Newborns in Jordan=約旦新生兒胎兒血紅素及其γ鏈三重基因之研究 |
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作 者 | Sadiq,May Fouad George; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷 期 | 22:3 1998.07[民87.07] |
頁 次 | 頁108-113 |
分類號 | 417.517 |
關鍵詞 | 新生兒; 胎兒血紅素; Gamma gene; Hemoglobin F; Hemoglobin S; Gene triplication; |
語 文 | 英文(English) |
英文摘要 | Quantitation of fetal hemoglobin (Hb F) and quantitation of it's g chain composition is important for the identification of different hemoglobinopathies. This is the first study done on the Jordanian newborns to test the hematological data and the gamma globin chain variants. A total of 52 randomly selected healthy Jordanian newborns were examined. The quantitation of the Gg and Ag chains combined with gene mapping using XmnI digestion, were used in the identification of one case of Gg triplication among the studied samples. A family study of this case showed that adults carrying one copy of this Gg triplication (13Kb XmnI fragment) had normal levels of HbF (< 1%) and high levels of Gg (> 80%) while no homozygotes were detected. The remaining 51 newborns had normal frequency values of Gg and Ag chains. The frequency of the AgT chain among the 52 samples was 0.22. No abnormal a or b chain variants were detected except for one case of HbS. |
本系統中英文摘要資訊取自各篇刊載內容。