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題 名 | 茄紅素對小鼠體內抗氧化狀態之影響 |
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作 者 | 王銘富; 許雯瑛; 詹吟菁; | 書刊名 | 美容科技學刊 |
卷 期 | 2:2 民94.08 |
頁 次 | 頁139-147 |
分類號 | 346.7 |
關鍵詞 | 茄紅素; 抗氧化; 老化促進小鼠; Lycopene; Antioxidation; Senescence accelerated mice; SAMP8; |
語 文 | 中文(Chinese) |
中文摘要 | 研究指出茄紅素(Lycopene)具有良好的抗氧化功效。本研究目的為探討茄紅素的給予對小鼠體內抗氧化狀態之影響。實驗以六月齡雄性老化促進小鼠(senescence accelerated mice, SAMP8)為對象,分為對照組、4、20及100 ppm茄紅素組,為期12週。實驗期間記錄攝食量、攝水量、體重變化及老化指數之評估。犧牲後檢測肝臟中超氧歧化酶(SOD)、觸酶(catalase)活性以及丙二醛(MDA)與總含硫化合物含量。結果顯示實驗各組攝食量、體重變化於四組間均無顯著差異;而攝水量方面茄紅素組與對照組相比為顯著增加(p<0.05)。肝臟SOD方面20、100ppm茄紅素組顯著高於對照組(p<0.05);20ppm茄紅素組之catalase活性與對照組相比為顯著增加(p<0.05)。20、100ppm茄紅素組之肝臟MDA生成量比對照組顯著降低(p<0.05)。綜合以上結果,補充茄紅素可有效提高老化促進小鼠肝臟抗氧化防禦系統。 |
英文摘要 | Lycopene was demonstrated to has antioxidant capacity. The purpose of this study was to investigate the effect of lycopene on antioxidative status in mice. Six-month-old senescence accelerated male mice were divided into four groups: control group、4、20、100 ppm lycopene (experimental group). After 12 weeks of feeding, body weight, food intake, drink amount were performed during the experiment. The activity of superoxide dismutase (SOD), catalase and malondialdehyde (MDA), total thiol concentrations in the liver were analyzed after sacrificed. The results showed that there were no significant differences in the body weight, food intake were no significantly among four groups. The drink amount of experimental groups were higher than the control group (p<0.05). The SOD activity of liver, 20、100 ppm lycopene groups were significantly higher than control group (p<0.05). The liver catalase activity of 20 ppm lycopene group was significantly higher than control group (p<0.05). The MDA concentrations of liver in the 20、100 ppm lycopene groups were significantly lower than control group. From the findings of these results, the supply of lycopene may improve antioxidative system on liver in SAMP8 mice. |
本系統中英文摘要資訊取自各篇刊載內容。