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題名 | 胞磷膽鹼、乳清酸、輔酶Q[fede]對仔鼠學習記憶及抗氧化狀態之影響=Effects of Citicoline, Orotic Acid and CoQ[fede] on Learning Memory Ability and Antioxidative Status in Mice |
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作者姓名(中文) | 王銘富; 蔡進唐; 蕭麗如; 楊美都; 黃克峰; | 書刊名 | 美容科技學刊 |
卷期 | 3:1 民95.02 |
頁次 | 頁137-148 |
分類號 | 373.1 |
關鍵詞 | 胞磷膽鹼; 乳清酸; 輔酶Q[fede]; 學習記憶; 抗氧化; Citicoline; Orotic acid; CoQ[fede]; Learning and memory; Antioxidation; |
語文 | 中文(Chinese) |
中文摘要 | 胞磷膽鹼(citicoline)、乳清酸(orotic acid)、輔酶Q10(Coenzyme Q10)皆具促進腦部發育功能。本研究目的為探討胞磷膽鹼、乳清酸、輔酶Q10分別餵食懷孕母鼠及其所生子代小鼠,對仔鼠學習記憶及抗氧化狀態之影響。將2月齡ICR懷孕六代母鼠分為對照組、0.05%胞磷膽鹼組、0.05%乳清酸組、0.5%輔酶Q10組四組,餵食至所生小鼠離乳;繼續餵食小鼠至8週齡。小鼠於實驗期間記錄攝食量、體重變化;在行為方面進行活動量試驗,並以單次被動迴避試驗及主動迴避試驗評估學習記憶能力。犧牲後檢測肝臟中超氧歧化酶、麩胱苷肰過氧化酶活性及丙二醛含量。結果顯示,子代ICR小鼠餵食不同實驗飼料後,體重及攝食量各組。每為活動量測試方面,對照組與實驗組間無顯著性差異。在學習記憶試驗方面,經主動迴避試驗後;各實驗組之逃脫反應顯著低於對照組(p<0.05),表示其學習記憶能力較佳。另外,經被動迴避試驗後,各實驗組於測試後之第1、2天,其學習記憶能力均較對照組佳(p<0.05)。肝臟抗氧化測定方面,實驗組超氧歧化酶、麩胱苷肰過氧化酶活性均顯著高於對照組(p<0.05)。實驗組之肝臟MDA生成量均顯著低於對照組(P<0.05)。綜合以上結果,給予胞磷膽鹼、乳清酸、輔酶Q10可促進小鼠腦耜發育,增進小鼠學習記憶並增加抗氧化狀態。 |
英文摘要 | The purpose of this study was to examine the effects of Citicoline, Orotic acid and CoQ10 on learning memory ability and antioxidative status in mice. Two month-old female pregnancy ICR mice were divided into four groups : casein diet group (the control group), casein diet supplemented with 0.5% Citicoline, 0.5% Orotic acid or food intake, open field activity test, single-trial passive avoidance test, shuttle avoidance test were performed during the study. The activity of superoxide dismutase (SOD), Gtathioneperoxidase (GSH Px) and malondialdehyde (MDA) in the liver were analyzed after sacrificed. The results showed that there were no significant differences in the body weight, food intake were no significantly aong four groups. In open fields activity test, the locomotion of control and experimental groups were no significant differences. In learning and memory, control group had significant lower memory ability than experimental groups of test through single-trial passive avoidance test(p<0.05%). In active shuttle avoidance test, control group had significant lower in learning and memory liability than experimental groups (p<0.05). the SOD, GPx activity of liver experimental groups were significant higher than control group (p<0.05). the MDA concentrations of liver in experimental groups were significant lower than control group (p<0.05). in summary, the supplement of Citicoline, Orotic acid and CoQ10 could improve the development of brain, learning memory ability and antioxidative status in ICR mice. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。