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題 名 | Titin在橫紋肌之肌節的建構及功能=Titin: Architecture and Function in the Sarcomere of Striated Muscle |
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作 者 | 陳思萍; 林自勇; 陳頤之; | 書刊名 | 長庚科技學刊 |
卷 期 | 3 2004.12[民93.12] |
頁 次 | 頁9-21 |
分類號 | 361.19 |
關鍵詞 | 肌原纖維蛋白; 肌節構造; Titin激酶; Myofibrillar proteins; Sarcomeric structure; Titin; Titin kinase; |
語 文 | 中文(Chinese) |
中文摘要 | Titin(亦稱connectin)是巨大的肌原纖維蛋白(分子量約3,000 kDa) ,其組成橫紋肌之肌節的彈性肌絲、系統。Titin的含量在所有肌肉蛋白總量中佔第三位(約10%),僅次於肌凝蛋白(myosin)及肌動蛋白(actin)。單一titin分子自Z線延伸至M線而橫跨半個肌節,其藉著和許多蛋白質的交互作用而調節肌節的組合及完整性。一般認為titin負責提供骨酪肌與心肌之被動張力,如此回復力可使肌節在伸展後得以恢復至最初狀態。A帶中的titin經由肌凝蛋白結合蛋白而與肌凝蛋白緊密結合,這將有助於肌節組合。在I帶中,titin具有下列特殊構造:縱列的重複免疫球蛋白區域以及富含PEVK四種胺基酸的片段,使titin分子在I帶中具有彈簧般的伸縮性,提供彈力以使粗肌絲穩定位於橫紋肌肌節中央。近來發現titin激酶本身是一種絲胺酸與酥胺酸激酶,含有調控片段、催化片段及絲胺酸的磷酸化位置。Titin的自主磷酸化可能與肌肉收縮時的訊息傳遞以及肌原纖維生成作用有關。此外,titin也和Duchenne肌肉萎縮症、Fukuyama型先天性肌肉萎縮症、胸腺瘤伴隨重症肌無力、脛前肌萎縮症等肌肉病變有密切的牽連性。本文回顧近年來的文獻以探討titin的構造及功能,而titin激酶的重要角色以及titin與染色體連結的證據將一併討論。 |
英文摘要 | Titin (also known as connectin), giant myofibrillar protein (3,000 kDa), consists of the elastic filament system of striated sarcomere. After myosin and actin, titin is the third most abundant (10%) muscle protein. An individual titin molecule spans the half sarcomere from Z line to the M line. It regulates the assembly and integrity, of sarcomeres by interacting with numerous proteins. Titin was assumed to be responsible for the passive tension in the skeletal and cardiac muscle fibers, and thus provides the restorative force to recover sarcomeres to the initial state after stretching. The A-band titin binds to myosin by myosin binding protein C, and thereby contributes to sarcomere assembly. In the I-band, titin contains two specific repeat motifs: tandem-poly-immunoglobulin modules and PEVK-rich domains. A spring-like unfolding and refold of titin's I-band domains confer extensibility to keep the thick filaments poised in the middle of the striated sarcomere. Recent evidence indicates that titin kinase is a serine/threonine kinase that contains regulatory tail, catalytic domain, and serine phosphorylation sites. Autophosphorylation of titin kinase may be involved in signal transduction of muscle contraction and myofibrillogenesis. In addition, titin has been implicated in several muscle diseases, e.g. Duchenne muscular dystrophy, Fukuyama type congenital muscular dystrophy, myasthenia gravis and thymoma, and tibialis muscular dystrophy. This article seeks to review current literatures ofthe structural and functional properties oftitin. The key role of titin kinase and the evidences of chromosomal titin are also discussed. |
本系統中英文摘要資訊取自各篇刊載內容。