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頁籤選單縮合
題 名 | Parathyroid Hormone Enhances Osteoblast Differentiation: An in Vitro Study=副甲狀腺素增進造骨細胞分化的體外研究 |
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作 者 | 史中; | 書刊名 | 中華民國口腔顎面外科學會雜誌 |
卷 期 | 15:2 2004.09[民93.09] |
頁 次 | 頁85-91 |
分類號 | 364.6721 |
關鍵詞 | 骨質密度; 造骨細胞; 骨質疏鬆; 副甲狀腺素; Bone mineral density; Osteoblast; Osteoporosis; Parathyroid hormone; |
語 文 | 英文(English) |
中文摘要 | 年齡增長後,骨量 (或骨質密度) 的下降易造成骨質疏鬆的發生,進而增加骨折發生的機會。骨折後除了影響骨組織外,同時可能涉及周圍的軟組織,最後導致局部組織功能喪失甚至危及生命。由最新文獻得知,骨質疏鬆患者或動物若施予低劑量副甲狀腺素可以增加骨量。另外,副甲狀腺素可以增加皮質骨體積和預防卵巢切除後骨質流失的情形。但是,到目前為止,副甲狀腺素對骨中細胞 (bone cell ) 分化的實際作用為何仍不清楚。因此,本研究旨在探討低劑量副甲狀腺素對造骨細胞分化的實際效應。研究中使用MC3T3-El細胞,並藉由細胞培養系統、氫三放射性標定胸腺嘧啶評估法、鹼性磷酸酶活性評估法、第一型膠原蛋白合成評估法、骨組織形態學測量法和光源鏡檢來進行實驗結果之計量和分析。結果發現:與對照組比較,低劑量副甲狀腺素顯著地增加造骨細胞增生 (p<0.01及0.005) 和造骨細胞鹼性磷酸酶活性 (p<0.05及0.01),但對第一型膠原蛋白合成則無明顯影響。因此,本研究結果顯示,低劑量副甲狀腺素有效地增進造骨細胞分化。 |
英文摘要 | With aging, the decrease in bone mass (or bone mineral density) could cause osteoporosis or increase the occurrence of fracture. It ultimately involves all the soft tissues in the injured area as well as the bone, resulting in loss of function or even death. Current evidences showed that there is an increase in bone mass in both osteoporotic patients and animals treated with low dose of parathyroid hormone (PTH). In addition, PTH could increase cortical bone volume and prevent postovariectomized osteopenia. However, the precise effect of PTH on bone cell differentiation is still unclear. The purpose of this study was to investigate the precise effect of low dose PTH on osteoblast differentiation. Cell culture system, 3H-thymidine incorporation assay, alkaline phosphatase activity assay, type I collagen synthesis assay, static and dynamic bone histomorphometry and light microscopy were performed on MC3T3-E1 cells. Low dose of hPTH (human PTH) significantly increased osteoprogenitor cell proliferation (p<0.01 and 0.005) and osteoblastic alkaline phosphatase activity (p<0.05 and 0.00 while no evidence of significant effect on collagen synthesis. In conclusion, low dose of PTH effectively enhances osteoblast differentiation. |
本系統中英文摘要資訊取自各篇刊載內容。