查詢結果分析
來源資料
相關文獻
- Possible Application of Milk Oligosaccharides for Drug Development
- Characterization of Hepatitis B e Antigen from Human Breast Milk
- 血型不相容活體腎臟移植之藥品治療
- 臺灣人的來源--DNA的探索
- 人類血型的遺傳
- cDNA Cloning and Expression Analysis of the Human UDPglucose Dehydrogenase
- The Effects of Pesticides Chlordane, Dieldrin and Endosulfan on the Growth of Human Breast Cancer Cell Lines MCF-7 and SK-BR-3
- 原型及固定化乳糖酶在乳糖水解過程中寡糖形成之比較
- 臺灣黃牛與荷蘭牛血型之比較
- Second-Trimester Maternal Serum Levels of Alpha-Fetoprotein, Free β-Subunit of Human Chorionic Gonadotropin and CA-125 in Twin Pregnancy after Multifetal Pregnancy Reduction
頁籤選單縮合
題 名 | Possible Application of Milk Oligosaccharides for Drug Development=乳汁中寡醣成為藥物的可行性 |
---|---|
作 者 | 木幡陽; | 書刊名 | 長庚醫學 |
卷 期 | 26:9 2003.09[民92.09] |
頁 次 | 頁620-636 |
分類號 | 346.217 |
關鍵詞 | 乳汁; 人類; 寡醣; 腸內菌; 血型; β3-N-乙醯葡萄醣胺移轉酶; Milk; Human; Oligosaccharides; Enteric bacteria; Blood types; β3-N-acetylglucosaminyltransferase; |
語 文 | 英文(English) |
中文摘要 | 使用指印法(finger-printing method)去分析人乳中的寡醣,發現在非分泌型(non-secretor)及路易士陰性(Lewis negative)個體的乳汁中缺乏一些寡醣。這個發現提供了一些線索來解釋人類血型與酵素的關係。此外,從一些含量較多寡醣的消失導致發現五種新的且含量較少的寡醣,而這些含量較少的寡醣是隱藏在含量較多的寡醣之中。後來在超過七十種不同構造的寡醣因而被發現。這些寡醣以十一種核心寡醣之中。後來,有超過七十種不同構造的寡醣因而被發現。這些寡醣是以十一種核心寡醣(core oligosaccharide)為基礎,經過唾液醣化(sialylation)及/或岩藻醣化(fucosylation)的衍生而成。其共同特點是在它們的還原端皆含有乳醣(lactose)。這個證據加上在人類兩種血型的乳汁中所見的到的刪除(deletion)或缺乏現象,顯示出這些寡醣是醣類移轉?群(glyoscyltransferases)藉由同時作用(concerted action)而形成,而這些酵素也窅責上皮細胞黏膜上醣蛋白中醣鏈的形成。寡醣的加長是藉由一懂iGnT(酵素)的作用而開始。這個酵素是負責將β-N-乙醯葡萄醣胺(β-N-acetylglucosamine, β-GlcNAc)平乳醣(galactose, Gal)第三個碳的位置成為G1cNAcβ1→3Gal的結構,使其可以繼續構成醣共軛上醣鏈的N-乙醯乳醣胺(N-acetyllactosamine, G1cβ1→4GalNAc)。因此,人乳寡醣包含的許多構造,都是經由N-乙醯乳醣胺(N-acetyllactosamine, G1cβ1→4GalNAc)連接到不同醣蛋白的醣鏈而開始的。 許多實驗證實,致病腸內菌與濾過性病毒上所含的凝集素(Lectin, adhestion or agglutinin)與目標細胞表面上特定醣共軛的醣鏈相結合開始進要感染。而人乳寡醣可用以阻撓並抑制這些細菌與濾過性病毒的附著而避免感染。 |
英文摘要 | By applying a finger-printing method to the analysis of human milk oligosaccharides, several oligosaccharides were found to be deleted in the milk of non-secretor or Lewis negative individual. This finding afforded a clue to elucidate the enzymatic basis of blood types in humans. Furthermore, disappearance of some major oligosaccharides led to the finding of five novel minor oligosaccharides, which were hidden under the major oligosaccharides. Later on, structures of more than seventy oligosaccharides were elucidated. These oligosaccharides are derived from eleven core oligosaccharides by sialylation and/or fucosylation. All these oligosaccharides contain lactose at their reducing termini. This evidence, together with the deletion phenomena found in the milk of two blook type individuals, suggested that the oligosaccharides are formed by the concerted action of glycosyltransferases, which are responsible for formation of the sugar chains of glycoproteins on the surface of epithelial cells constructing the mucous membrane. The elongation may start by the action of iGnT. This enzyme is responsible for the addition of aβ-N-acetylglucosamine residue to the C-3position of the glycoconnjugates therefore, oligosaccharides in human milk may include many structures, starting from the N-acetyllactosamine residues in the sugar chains of various glycomproteins. Many evidences, which indicate that virulent enteric bacteria and viruses start their infection by binding to particular ssugar chains of glycoconjugates on the surface of their target cells, were presented recently. Therefore, milk oligosaccharides are expected to be useful to inhibit the infection of these bacteria and viruses. . |
本系統中英文摘要資訊取自各篇刊載內容。