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題名 | The Effects of Pesticides Chlordane, Dieldrin and Endosulfan on the Growth of Human Breast Cancer Cell Lines MCF-7 and SK-BR-3=殺蟲劑氯丹、地特靈和安殺番對人類乳癌細胞株MCF-7和SK-BR-3生長影響的探討 |
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作者 | 徐濟泰; 應靜雯; 藍心婕; Hsu, Jih-tay; Ying, Chingwen; Lan, Hsin-chieh; |
期刊 | 中國農業化學會誌 |
出版日期 | 19981200 |
卷期 | 36:6 1998.12[民87.12] |
頁次 | 頁535-546 |
分類號 | 416.226 |
語文 | eng |
關鍵詞 | 環境污染物; 殺蟲劑; 人類乳癌細胞; Environmental pollutants; Pesticides; Human breast cancer cells; |
中文摘要 | 環境中存在的一些人造化學污染物質,如殺蟲劑,塑膠中的成分,界面活性劑等, 因其具有雌激素或抗雌激素等類似人類荷爾蒙的活性,對人類和其他動物內分泌和生殖的正 常功能造成潛在性的影響,並可能與人類乳癌和睪丸癌的產生有密切的相關性。本研究對環 境中這些具有荷爾蒙作用殺蟲劑影響對人類乳癌細胞生長的現象進行探討,以評估這些環境 污染物對人類之可能的影響。實驗結果顯示這些污染物質對人類乳癌細胞的生長具有顯著的 影響,且其影響與處理濃度有關,氯丹濃度對MCF-7細胞的生長,具有雙相的影響。低濃度 時對細胞的生長具有促進作用,且此作用須細胞內雌激素受器的存在,高濃度處理時,則對 細胞的生長具有抑制作用,此作用似與細胞中的雌激素受器無關。當二種或二種以上的這些 化學物質存在時,其對細胞生長的抑制,有顯著加成的效果。這些現象表示環境中具荷爾蒙 活性的污染物質對人類的影響及其安全標準,可能須進一步的探討,以期能正確評估這些污 染物質對人類健康的衝擊。 |
英文摘要 | Certain environmental pollutants exhibit endocrine-disrupting hormonal activity. They can interfere with teh reproduction systems of human and other animals. These chemicals include pesticides, the plastics ingredient bisphenol-A , non-ionic surfactants (alkylphenol-polyethoxylates or APnEO, n=9-90) and some polychlorinated biphenyls (PCBs). In this study, the influences of these pesticide, namely chlordane, endosulfan and dieldrin on the growth of human breast cancer cells were examined to evaluate their impacts on human. Results showed that these chemicals exhibited significant effects on the growth of human breast cancer cells and their effects appeared to be biphasic. At concentrations of 1.75 M, chlordane induced the growth proliferation of MCF-7 cells which contained estrogen, chlordane recep tors, while no stimulation effect was observed in SK-BR-3 cells, an estrogen receptor negative cell line. At concentrations above 87.5 M, these chemicals showed inhibitory effects on the growth of both cell lines. Combination of these environmental chemicals had apparent synergistic action on the gowth inhibition of human breast cancer cells. It thus suggests that the effects of these environmental chemicals may be mediated through two separate pathways, and the impacts of these environmental pollutants on human and the safety margin, which may be a lot smaller than has been anticipated, may need to be further examined. |
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