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題 名 | The Declined Effects of Ubiquinone Biosynthesis on by Gavaged Monascus Rice Powder in ICR Mice=急性灌食紅麴粉末對雄性ICR小鼠肝藏、心臟泛醌濃度之影響 |
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作 者 | 謝孟志; 楊惠婷; 劉佩姎; 錢信; 劉姚伶; 謝明哲; 黃士懿; | 書刊名 | 大仁學報 |
卷 期 | 20 2001.06[民90.06] |
頁 次 | 頁73-83 |
分類號 | 369.36 |
關鍵詞 | 泛醌; 紅麴粉末; 灌食; Monascus rice powder; Coenzyme Q[fede]; Gavage; |
語 文 | 英文(English) |
中文摘要 | 本研究旨在探討以ICR小鼠灌食大量之紅麴粉末對小鼠心臟及肝臟細胞中泛醌(CoQ)之影響。實驗將88隻成熟雄性ICR小鼠隨機分成3組,其中控制組8隻,低劑量組與高劑量組各40隻。將不同量(低劑量組:每公斤體重1公克,高劑量組每公斤體重5公克)之紅麴粉末溶於大豆油中分別灌食於各組實驗小鼠,控制組則僅以純大豆油灌食之。控制組於灌食後隨即犧牲,實驗組則分別在不同時間點下(第30、60、90分鐘,第4及24小時)予以犧牲,取其心臟及肝臟作泛醌濃度及肝臟monacolin K的分析。結果發現投予紅麴粉末之小鼠於30分鐘後其心臟及肝臟中泛醌的濃度皆明顯下降(P<0.05),而且經過24小時亦無法回到原始濃度。以劑量觀點得知,高劑量組對降低肝臟泛醌濃度明顯大於低劑量組(P<0.05),心臟也有同樣之情況,唯變化較慢,相對於肝臟在60分鐘後可見泛醌濃度驟降,心臟中則需90分鐘後始見其降低現象。而肝臟中monacolin K濃度則隨時間增長而逐漸降低。綜合以上所述,紅麴粉末會抑制成熟雄性ICR小鼠心臟及肝臟內泛醌之濃度,而且隨著劑量的增加抑制效果亦隨之增強。此外,亦發現當鼠體進食大量紅麴時,先影響肝臟中泛醌濃度,其次為心臟。 |
英文摘要 | The proposed study was to evaluate the effect of high quantity rice powder of Monascus on cardiac and hepatic coenzyme Q₁₀ synthesis in ICR mice. Eighty-eight adult male ICR mice were adjusted, housed, and divided into control and experimental groups of Monascus rice powder treated groups. The animals were gavaged with different doses of Monascus rice powder dissolved in soybean oil (1 g/kg body weight for low dose and 5 g/kg body weight for high dose). After gavaged, the animal of control group were sacrificed immediately; the mice of experimental groups (8 for each subgroup) were sacrificed with different time intervals such as 1/2, 1, 11/2, 4 and 24 hours, respectively. Liver and heart were taken for monacolin K and CoQ₁₀ analysis. Result showed that liver and heart CoQ₁₀ levels were dramatically declined in both of the administered groups, especially in the high dose group at 30 minutes. After 24hr, the levels of hepatic and cardiac CoQ₁₀ were still remained in the lower levels. A similar trend was also observed in heart, whereas the inhibitory effect began after 90min. From the administrated dosage of view, high dose of Monascus rice powder presents more suppressive effect than lower dose group on tissue CoQ₁₀ levels. In conclusion, Monascus rice powder indeed suppresses the hepatic and cardiac CoQ₁₀ level in rodents. The higher the dosage of Monascus rice powder, the lower the CoQ₁₀ levels in liver and heart. |
本系統中英文摘要資訊取自各篇刊載內容。