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題 名 | The Influence of Age and Gender on HLA-DR in Chinese Child-Onset Type 1 Diabetes Mellitus Patients=中國人兒童期發作第一型糖尿病其HLA-DR受發作年齡及性別之影響 |
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作 者 | 陳百薰; 蔣雯; 顏正賢; 趙美琴; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 16:8 2000.08[民89.08] |
頁 次 | 頁393-399 |
分類號 | 417.5937 |
關鍵詞 | 兒童期; 第一型糖尿病; 白血球組織抗原基因; 發作年齡; 性別; Type 1 diabetes mellitus; HLA DR; Age at onset; Gender; PCR-SSP; |
語 文 | 英文(English) |
中文摘要 | 白血球組織抗原(HLA) 基因之某些對偶基因和第一型糖尿病之致病性 有密切關係。為了進一步闡明HLA-DR 對偶基因和第一型糖尿病之關係以及發 作年齡及性別對HLA-DR之影響,吾人研究76位兒童期發作之中國人第一型糖 尿病人和154位正常對照組者之HLA-DR。吾人使用聚合酵素連鎖反應特異性序 列引子 (PCR-SSP)。第一型糖尿病人其平均發作年齡為8.43 + 3.96歲。吾人研 究結果顯示第一型糖尿病人其DR3, DR4, DR9之頻率有意義的高於對照組者 ( all P < 0.01)。第一型糖尿病者致病性對偶基因為DR3, DR4, DR9,其相對危險 率分別為8.25, 2.57, 2.67。第一型糖尿病童的保護性對偶基因為DR2, DR8, DR11, DR12,其相對危險率分別為0.24, 0.15, 0.16, 0.39 ( p <0.01, <0.01, <0.05, <0.05)。 第一型糖尿病者男女性其HLA DR3, DR4, DR9, DR3/4, DR3/9, DR4/9之頻率無 有意義之差異。吾人將第一型糖尿病童依照其發病年齡分為三群 (1-5歲, 6-10 歲, 11-17歲)。HLA DR9之頻率隨著發作年齡增加而逐步減少,但是第一型糖尿 病人發作年齡6-10歲及11-17歲群其DR3, DR4, DR9, DR3/4, DR3/9, DR4/9之頻 率並無有意義之差異。至於性別對HLA基因型之影響,雖然在男性病童方面有 DR3/4之頻率隨發作年齡增加而減少之趨勢,而在女性病童方面DR3/4之頻率隨 發作年齡增加而增加,但是第一型糖尿病童0-10歲和11-17歲兩群之間其DR3, DR4, DR9, DR3/4, DR3/9, DR4/9之頻率無統計學上有意義之差異。 |
英文摘要 | To further clarify the association of HLA DR alleles with type 1 diabetes mellitus and the influence of age-onset and gender on type 1 diabetes, we investigated HLA-DR in 76 child onset Chinese (36 males) type 1 diabetes patients and 154 normal controls by using PCR-SSP (sequence specific primer). The mean age of onset of diabetes patients was 8.43 +/- 3.96 year-old. Our results revealed that the frequencies of DR3, DR4 and DR9 in diabetes patients were significantly higher than those in control group (all P < 0.01). The susceptible alleles were DR3, DR4, DR9, with relative risks of 8.25, 2.57 and 2.67, respectively. The protective alleles to type 1 diabetes were DR 2, DR8, DR11 and DR12 with relative risk of 0.24, 0.15, 0.16 and 0.39, respectively. There were no significant differences between the frequencies of HLA DR 3, DR4, DR9, DR3/4, DR3/9 and DR4/9 in male and female diabetic children. We divided the diabetes patients into three groups according to their age of onset (1-5 years old, 6-10 years old and 11 - 17 years old). There was a trend that the frequencies of DR9 decreased with the increase of age at onset, but there was no significant difference of DR3, DR4, DR9, DR3/4, DR3/9 and DR4/9 frequencies between diabetes children with age onset 0-10 years and 11-17 years. As to the influence of gender on the HLA genotypes, the frequency of DR3/4 decreased with the increase of age at onset for male patients and the frequency of DR3/4 increased with the increase of age at onset for female patients. |
本系統中英文摘要資訊取自各篇刊載內容。