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頁籤選單縮合
題 名 | Mutation Analysis of PTEN/MMAC1 in Sporadic Thyroid Tumors=偶發甲狀腺腫瘤中,PTEN/MMAC1基因突變分析 |
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作 者 | 謝明家; 林勝豐; 辛錫璋; 劉大智; 張建國; 李菁萍; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 16:1 2000.01[民89.01] |
頁 次 | 頁9-12 |
分類號 | 415.931 |
關鍵詞 | 甲狀腺腫瘤; 基因突變; 腫瘤抑制基因; PTEN/MMAC1 gene; Thyroid tumor; Direct sequence; |
語 文 | 英文(English) |
中文摘要 | 最近,一個腫瘤抑制基因,PTEN/MMAC1,在染色體10q23.3的區域內被確定。這個 基因轉譯出來的蛋白質為含有403個胺基酸組成雙特異性的磷酸,而此磷酸中有一部分和 tensin及auxillin是相同的。在癌細胞株及某些癌中,PTEN/MMAC1體細胞基因突變曾被發現。 Cowdendisease,為一自體顯性遺傳的缺陷瘤症候群,和因狀腺和乳房腫瘤有關,曾被發現有 PTEN/MMAC1基因突變。為了評估PTEN/MMACl基因在甲狀腺腫瘤的角色,我們研究17個偶發性 甲狀腺腫瘤,包括12個甲狀腺乳突癌,l個甲狀腺濾泡癌,l個甲狀腺髓質癌及3個甲狀腺腺瘤。 我們以核酸定序法分析PTEN/MMAC1,9個exon經聚合連鎖反應的產物.並無任何PTEN/MMAC1 基因突變被發現,我們的結果顯示PTEN/MMAC1基因在偶發甲狀腺腫瘤中扮演的角色可能不大。 d carcinomas, l was fol1icular thyroid carcinoma, l was medullary thyroid carcinoma and 3 were thyroid adenomas. Direct sequencing of PCR-amplified products was performed for all nine exons of PTEN/MMACl. No mutationsofPTEN/MMACl gene were observed in any of the sporadic thyroid tumors. Our results indicate that the PTEN/MMACl gene may not play a major role in sporadic thyroid tumors. |
英文摘要 | Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3. This gene encodes a 403 amino acid dual specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been found in a number of cancer cell lines and primary cancers. Cowden disease, an autosomal dominant harmartoma syndrome associated with thyroid and breast tumors, has been found to be associated with mutations of PTEN/MMAC1 gene. To evaluate the role of the PTEN/MMAC1 gene in sporadic thyroid tumors, we studied 17 sporadic thyroid tumors, of which 12 were papillary thyroid carcinomas, 1 was follicular thyroid carcinoma, 1 was medullary thyroid carcinoma and 3 were thyroid adenomas. Direct sequencing of PCR-amplified products was performed for all nine exons of PTEN/MMAC1. No mutations of PTEN/MMAC1 gene were observed in any of the sporadic thyroid tumors. Our results indicate that the PTEN/MMAC1 gene may not play a major role in sporadic thyroid tumors. |
本系統中英文摘要資訊取自各篇刊載內容。